laudanosine


Also found in: Encyclopedia.

lau·da·no·sine

(law'dă-nō-sēn),
An isoquinoline alkaloid obtained from the mother liquor of morphine; it causes tetanic convulsions.

laudanosine

Anesthesiology A metabolite of atracurium, an intermediate-acting nondepolarizing muscle relaxing anesthetic; laudanosine is epileptogenic, crosses the blood-brain barrier, and may accumulate in the elderly, and in renal failure. See Muscle relaxant. Nondepolarizing agent. Cf Depolarizing agent.
References in periodicals archive ?
Laudanosine, an atracurium and cisatracurium metabolite.
Use of neuromuscular blocking agents in acute respiratory distress syndrome
Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines.
Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities
Other compounds structurally related to the aporphines, as the benzyltetrahydroisoquinolines (cularine, isocrasifoline and laudanosine) and the bisbenzyltetrahydroisoquinolines (antioquine, tetrandine) are also described as inhibitors of the C[a.sup.+2] influx through voltage-operated calcium channels (Ivorra et al., 1992, 1993a).
Nantenine alkaloid presents anticonvulsant effect on two classical animal models
Medical browser ?
Full browser ?