An isoquinoline alkaloid obtained from the mother liquor of morphine; it causes tetanic convulsions.
Anesthesiology A metabolite of atracurium, an intermediate-acting nondepolarizing muscle relaxing anesthetic; laudanosine is epileptogenic, crosses the blood-brain barrier, and may accumulate in the elderly, and in renal failure. See Muscle relaxant. Nondepolarizing agent. Cf Depolarizing agent.
Other compounds structurally related to the aporphines, as the benzyltetrahydroisoquinolines (cularine, isocrasifoline and laudanosine) and the bisbenzyltetrahydroisoquinolines (antioquine, tetrandine) are also described as inhibitors of the C[a.sup.+2] influx through voltage-operated calcium channels (Ivorra et al., 1992, 1993a).