late-phase response

late-·phase re·sponse

recurrence of symptoms after an appreciable interval following challenge with an antigen; preceded by an initial early-phase response.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Late-phase response to an allergic reaction is due to the migration of neutrophils, lymphocytes, eosinophils, and macrophages into the initial site.
We chose to perform an intracutaneous skin test rather than the usual skin prick test because intracutaneous injection of the allergen is the most feasible and convenient way to induce a late-phase response after the early-phase skin response [18].
4'-dihydroxyphenyl) ethyl-O-[alpha]-L-rhamnopyranosyl(l (1 [right arrow] 3)-[beta]-D-(4-0-caffeoyl)-glucopyranoside] from their ethylacetate fractions, respectively, and evaluated their anti-asthmatic effects on the aerosolized ovalbumin (OA) challenge in the OA-sensitized guinea-pigs measuring the specific airway resistance (sRaw) during the immediate-phase response (IAR) and late-phase response (LAR), and also measured recruitment of leukocytes and chemical mediators on the bronchoalveolar lavage fluids (BALF) in LAR, as well as histopathological survey.
Inhalation challenge in asthmatics can induce immediate-phase bronchocon-striction and a subsequent late-phase response associated with edema of the airway wall and lung inflammation.
Thus, basal activity differences, inhibitory antagonism, and late-phase response patterns may contribute heretofore unsuspected information used by the olfactory system in categorizing odorants.
The late-phase response is not histamine mediated; other studies have shown intranasal corticosteroids to inhibit the response.
Throughout the afternoon, this same morning allergen exposure produces a second wave, the late-phase response, consisting of more subtle symptoms such as nasal obstruction, fatigue, and sinus problems.
The late-phase response also makes the lungs more sensitive to other stimuli that produce asthma, such as changes in weather, fumes and odors.
Late-phase responses (two to eight hours after the initial stimulus) are due to recruitment of other cells, especially eosinophils, neutrophils and lymphocytes.
Allergic rhinitis is an IgE-mediated reaction to aeroallergens and is characterized by early-and late-phase responses. Both phases can manifest with sneezing, congestion, and rhinorrhea; congestion is predominant in the late phase.