late-phase reaction


Also found in: Acronyms.

de·layed re·ac·tion

a local or generalized response that begins 24-48 hours after exposure to an antigen involving sensitized T cells. See: cell-mediated reaction.
Synonym(s): contact hypersensitivity (2) , delayed hypersensitivity (2) , late reaction, late-phase reaction, tuberculin-type hypersensitivity

late-phase reaction

Inflammation of any part of the body caused by the release of cytokines; leukotrienes B4, C4, and D4; and prostaglandin D2, occurring approx. 6 hr after the body's initial response to an antigen, during a type I hypersensitivity response. Late-phase reactions play a significant role in prolonging illnesses such as asthma after the initial, immediate histamine-based response has subsided. These are treated with and prevented by the use of corticosteroids, such as prednisone, and other drugs.
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The new synthesis (over several hours) of further mediators is stimulated in both mast cells and basophils, contributing to the late-phase reactions in acute asthma.
Asthma--obstructing the airflow
It is a topical, inhaled antihistamine with anti-inflammatory properties that works on early-phase and late-phase reactions. It has been shown to be as effective as loratadine and beclomethasone used together.
Age of Child Impacts Allergic Rhinitis Diagnosis. (Early Treatment may avoid Comorbidities)
He said that there were no real adverse reactions with the anti-IgE antibody; it is different from traditional allergy immunotherapy, with no swelling or late-phase reactions.
Anti-IgE Succeeds in Severe Asthma, Rhinitis

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