The late endosomes then fuse with either lysosomes or autophagosomes for lysosomal degradation.
10] GTP-bound Rab7 regulates the early-to-late endosome transition and the maturation of late endosomes and late AVs.
The giant organelles in beige and Chediak-Higashi fibroblasts are derived from late endosomes
and mature lysosomes.
The formation of isolation membranes by trans-Golgi/endosomal fusion is also supported by studies showing a requirement for Rab9, which is a GTPase essential for the trafficking of proteins from late endosomes to trans-Golgi membranes.
The generation of autophagic vacuoles in alternative autophagy is mediated by the fusion of isolation membranes with vesicles derived from the trans-Golgi as well as late endosomes, in a Rab9-dependent manner.
CD1b and mouse CD1d (mCD1d) interact with AP-3, which sorts these molecules to the late endosomes
While the primary function of early lysosomes is sorting, late endosomes and lysosomes attempt to digest the internalized light chains.
35) Internalized light chains are then degraded mainly by late endosomes and, selectively, in combination with early lysosomes.
Overexpression of MARCH1 in HeLa cells causes CD98 to be trafficked via EEA1 positive compartments and late endosomes rather than clathrin independent endocytosis .
Expression of MARCH2 in COS7 cells lead to the relocalization of proteins that are transported in both early (TGN38/46) and late endosomes (furin and mannose-6-phosphate receptor) to MARCH2 positive stained vesicles in a manner that is dependent on SX6 and therefore indicating that MARCH2 regulates the retrograde transport of proteins to the TGN.
After internalization of bacteria, the endosome ceases to mature and does not accumulate markers of late endosomes
or phagolysosomes (27).