large offspring syndrome


Also found in: Acronyms.

large offspring syndrome

Neonatal respiratory and metabolic abnormalities l; a large and dysfunctional placenta is present. Often seen in offspring generated by nuclear transfer technology.
A constellation of postnatal defects seen in mammals cloned by nuclear transfer—most such clones are stillborn
References in periodicals archive ?
Cellular and molecular deviations in bovine in vitro-produced embryos are related to the large offspring syndrome. Biol Reprod 2002; 67:767-775.
This suggests that the "large offspring syndrome" may not be as common in human clones either, Killian and associates concluded.
Although there is an increased mortality rate compared to naturally conceived offspring and clones that survive to term frequently die early in life of "large offspring syndrome" (perhaps caused by known subtle differences in gene regulation even among animals derived from the same cell), the animals that survive "infanthood" appear to be normal.
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