large granular lymphocyte

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large granular lymphocyte

One of a range of larger-than-average lymphocytes with granules in the cytoplasm which function as natural killer and killer cells. The group also includes activated cytotoxic T cells.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

References in periodicals archive ?

To the Editor: Large granular lymphocytic leukemia (LGLL) is a rare chronic clonal lymphoproliferative disease characterized by a persistent increase in large granular lymphocytes, which are large lymphocytes with a low nucleus to cytoplasm ratio and an abundant cytoplasm with azurophilic granules.

Two Cases of Refractory Large Granular Lymphocytic Leukemia Treated by Porcine Anti-human Thymocyte Immunoglobulin

Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells.

Minimal disease detection and confirmation in hematologic malignancies: combining cell sorting with clonality profiling

To the best of our knowledge, so far, no individual cases of CD56 negative ANKL have been previously described in the literature, although a rare case of aggressive T cell large granular lymphocyte leukemia was recently reported [29], and a case series have revealed strong CD56 positivity in all but 5 cases of 43 (88.4%) of ANKL tested by flow cytometry (11).

CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review