large cell carcinoma


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Related to large cell carcinoma: adenocarcinoma

carcinoma

 [kahr″sĭ-no´mah] (pl. carcinomas, carcino´mata)
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue.
adenocystic carcinoma (adenoid cystic carcinoma) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
alveolar carcinoma bronchioloalveolar carcinoma.
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells, rarely metastatic but locally invasive and aggressive. It usually occurs as small pearly nodules or plaques on the face of an older adult, particularly on a sun-exposed area of someone with fair skin. It has been divided into numerous subtypes on the basis of clinical and histological characteristics.
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements.
bronchioalveolar carcinoma (bronchiolar carcinoma) (bronchioloalveolar carcinoma) (bronchoalveolar carcinoma) a variant type of adenocarcinoma of the lung, with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. Called also alveolar carcinoma or adenocarcinoma and bronchiolar, bronchioloalveolar, or bronchoalveolar adenocarcinoma.
bronchogenic carcinoma any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles, consisting of two layers of cells surrounding a minute lumen. Called also bile duct carcinoma and cholangiocarcinoma.
chorionic carcinoma choriocarcinoma.
colloid carcinoma mucinous carcinoma.
cylindrical cell carcinoma carcinoma in which the cells are cylindrical or nearly so.
embryonal carcinoma a highly malignant germ cell tumor that is a primitive form of carcinoma, probably of primitive embryonal cell derivation; it usually arises in a gonad and may be found either in pure form or as part of a mixed germ cell tumor.
epidermoid carcinoma squamous cell carcinoma.
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs.
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. It is rare in North America and Western Europe but is one of the most common malignancies in parts of sub-Saharan Africa, Southeast Asia, East Asia, and elsewhere. A strong association seems to exist with chronic hepatitis B virus infection.
Hürthle cell carcinoma a malignant Hürthle cell tumor.
carcinoma in si´tu a neoplasm whose tumor cells are confined to the epithelium of origin, without invasion of the basement membrane; the likelihood of subsequent invasive growth is presumed to be high.
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation.
medullary carcinoma that composed mainly of epithelial elements with little or no stroma.
mucinous carcinoma an adenocarcinoma that produces significant amounts of mucin.
nasopharyngeal carcinoma a malignant tumor arising in the epithelial lining of the nasopharynx, occurring at high frequency in people of Chinese descent. The epstein-barr virus has been implicated as a causative agent.
non–small cell carcinoma a general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.
oat cell carcinoma a form of small cell carcinoma in which the cells are round or elongated and slightly larger than lymphocytes; they have scanty cytoplasm and clump poorly.
papillary carcinoma carcinoma in which there are papillary growths that are irregular in nature arising from otherwise normal tissue; it can occur in the thyroid gland, the breast, or the bladder. Called also papillocarcinoma.
renal cell carcinoma carcinoma of the renal parenchyma, composed of tubular cells in varying arrangements; called also clear cell carcinoma.
scirrhous carcinoma carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma. Called also fibrocarcinoma.
carcinoma sim´plex an undifferentiated carcinoma.
small cell carcinoma a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells. Metastasis to the hilum and to mediastinal lymph nodes is common.
spindle cell carcinoma squamous cell carcinoma marked by development of rapidly proliferating spindle cells.
squamous cell carcinoma
1. carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization. Initially local and superficial, the lesion may later invade and metastasize.
2. the form occurring in the skin, usually originating in sun-damaged areas or preexisting lesions.
3. in the lung, one of the most common types of bronchogenic carcinoma, generally forming polypoid or sessile masses that obstruct the airways of the bronchi. It usually occurs in middle-aged individuals with a history of smoking. There is frequent invasion of blood and lymphatic vessels with metastasis to regional lymph nodes and other sites. Called also epidermoid carcinoma.
transitional cell carcinoma a malignant tumor arising from a transitional type of stratified epithelium, usually affecting the urinary bladder.
verrucous carcinoma
1. a variety of squamous cell carcinoma that has a predilection for the buccal mucosa but also affects other oral soft tissue and the larynx. It is slow-growing and somewhat invasive.
2. Buschke-Löwenstein tumor, so called because it is histologically similar to the oral lesion.

large cell car·ci·no·ma

an anaplastic carcinoma, particularly bronchogenic, composed of cells which are much larger than those in oat cell carcinoma of the lung.

large cell carcinoma

n.
A non-small cell lung cancer composed of large, undifferentiated cells.

large cell car·ci·no·ma

(lahrj sel kahr'si-nō'mă)
An anaplastic carcinoma, particularly bronchogenic, composed of cells that are much larger than those in oat cell carcinoma of the lung.
References in periodicals archive ?
The summary of chemotherapeutic researches of natural products against lung LCC and SCLC (59, 82, 83, 94-97) Natural products Sources Mechanisms of action Lung large cell carcinoma (LCC) Didymin Flavonoid glycoside In vitro: * Inhibited H460 from citrus fruits.
Large Cell Neuroendocrine Carcinoma (LCNEC) is no longer classified as a variant of large cell carcinoma. According to the new 2015 WHO classification [38], all lung tumors with neuroendocrine differentiation should be grouped together into one category--neuroendocrine tumors, including those of high grade SCLC and LCNEC, while the diagnosis of large cell carcinoma should be restricted only to small group of resected tumors that lack any clear morphological or immunohistochemical differentiation with reclassification of the remaining former large cell carcinoma subtypes into different categories.
Sputum analysis (n=90) Age 61 (37-89) Gender (M/F) 59/31 Smoking history Yes 37 No 15 Ex-smoker 38 Stage T 1 8 2 24 3 22 4 36 Stage N 0 14 1 76 Stage M 0 46 1 44 Histologic type Squamous cell carcinoma 32 Adenocarcinoma 56 Large cell carcinoma 2 Follow-up (months) 27 (7-88) Patients censored for survival analysis 32 at last time of follow-up Tissue analysis (n=46) Age 65 (44-84) Gender (M/F) 25/17 Smoking history Yes 25 No 15 Ex-smoker 6 Stage T 1 11 2 24 3 7 4 4 Stage N 0 25 1 21 Stage M 0 46 1 0 Histologic type Squamous cell carcinoma 13 Adenocarcinoma 27 Large cell carcinoma 6 Follow-up (months) 27 (7-88) Patients censored for survival analysis 32 at last time of follow-up Data are reported as number or median and range.
Adenocarcinoma was seen in 9 cases (33.34 %) and Large cell carcinoma was seen in only 3 case (11.11 %), Metastatic carcinoma in 2 cases (7.4%).
(b) SQCC, squamous cell carcinoma; Adeno, adenocarcinoma; and LCC, large cell carcinoma. Table 2.
All cases of large cell carcinoma (n= 2) and pleomorphic carcinoma (n= 1) were peripheral lung lesions.
NSCLC includes lung adenocarcinoma, lung squamous cell carcinoma (LSCC), and lung large cell carcinoma. Adenocarcinoma arises in the distal airway and its incidence is not related to smoking.
Moreover, there are a few reports in the literature indicating malignancy potential of bronchogenic cysts, such as converting into large cell carcinoma [11], bronchoalveolar carcinoma [12], adenocarcinoma, and squamous cell carcinoma [13].
Adenocarcinoma and Large cell carcinoma. (6) Despite advances in surgical techniques and combined therapies, lung cancer remains a disease with a dismal prognosis and overall 5-year survival has remained relatively unchanged at 12-16% over the past 30 years.
All other lung cancer phenotypes, including squamous cell carcinoma, neuroendocrine carcinoma, large cell carcinoma, and small cell carcinoma, were negative for all 3 markers.
The major histological classes of NSC carcinoma are adenocarcinoma, squamous cell carcinoma and large cell carcinoma.
Tumors with an original diagnosis of large cell carcinoma or NSCLC, not otherwise specified, were reclassified according to 2015 World Health Organization criteria as described in a prior study.

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