The study titled "Genome Sequence of the Lantibiotic
Bacteriocin Producer Streptococcus Salivarius Strain K12" was published in the Journal of Bacteriology (2012).
The naturally occurring lantibiotic
- a peptide produced by a harmless bacteria - is the first natural preservative found to kill gram-negative bacteria, typically the harmful kind.
2006, "Streptococcus macedonicus ACA-DC 198 produces the lantibiotic
, macedocin, at temperature and pH conditions that prevail during cheese manufacture," Int.
These include novel promising lantibiotic
candidates in pre-clinical testing for the treatment of Gram-positive infections including MRSA and novel broad spectrum bacteriocins for the treatment of both Gram-positive and Gram-negative infections.
ASSEMBLY OF THE LANTIBIOTIC
MUTACIN 1140 IN MEMBRANES
A selection of the extensive chapter titles reads: Lactic acid bacteria and bacteriocins - their practical importance; Taxonomy of lactic acid bacteria; Genetics and protein engineering of nisin; Lacticin 481, a lantibiotic
produced by Lactococcus lactis; Lactococcins, bacteriocins of Lactococcus lactis; Bacteriocins and bacteriocin-like substances from Lactobacillus; Lactacin F, a small hydrophobic heat-stable bacteriocin; Lactocin S, a lanthionine-containing bacteriocin isolated from Lactobacillus sake L45; Bacteriocins of Pediococcus; Bacteriocins produced by Leuconostoc species; Bacteriocins produced by Streptococcus thermophilus; Bacteriocins of Enterococcus; and Enterocin 1146, a bacteriocin produced by Enterococcus faecium DPC 1146.
This demonstrates significant progress toward the commercial production of its lead lantibiotic
, MU1140, and delivers an important step in validating the lantibiotics
platform targeting infectious diseases.
NYSE: OGEN) and Intrexon Corporation (NYSE: XON), a leader in synthetic biology, announced positive data on multiple compounds from Oragenics' Mutacin 1140 ("MU1140") lantibiotic
platform in a critical animal model study, as well as the selection of a lead clinical candidate.
difficile molecule, a new class of lantibiotic
The scientific paper, co-authored by Eefjan Breukink of Utrecht University in the Netherlands, is titled "An Alternative Bactericidal Mechanism of Action for Lantibiotic
Peptides that Target Lipid II.
He has discovered a new lantibiotic
, sublancin, which has been exclusively licensed to Antex.
In addition to the Lantibiotic
program, the Company plans to continue to grow and focus on its probiotic business through expansion internationally and domestically.