BT-11 is a first-in-class, orally-active, gut-restricted small molecule investigational new drug that targets the Lanthionine
Synthetase C-Like 2 (LANCL2) pathway that impacts the gastrointestinal tract.
BT-11 is a first-in-class, oral, gut-restricted small molecule therapeutic with a unique mechanism of action that targets a novel pathway called Lanthionine
Synthetase C-Like 2 (LANCL2).
It is reported that alkaline pH favors keratin degradation as cysteine residues are modified to lanthionine
making it vulnerable for hydrolytic action.
Nisin is an important bacteriocin AMP and one of the most studied lantibiotic which has a 34 amino acid including lanthionine
A derivative of the CRMP2 binding compound lanthionine
ketimine provides neuroprotection in a mouse model of cerebral ischemia.
Banerjee, "[H.sub.2]S biogenesis by human cystathionine y-lyase leads to the novel sulfur metabolites lanthionine
and homolanthionine and is responsive to the grade of hyperhomocysteinemia," The Journal of Biological Chemistry, vol.
More specifically, lantibiotics are an important family of heat stable low molecular weight bacteriocins that possess unusual posttranslationally modified amino acids, such as lanthionine
, methyllanthionine, dehydroalanine, and dehydrobutyrine with thioether linkages .
The exact phenomenon by which processing adversely affects the cysteine is not clear (Wang and Parsons, 1998) but might be due to lysinoalanine or lanthionine
formation (Robbins et al., 1980).
Diet B contained higher levels of digestible methionine, threonine, and lanthionine
(P < .05, Table 3).
Cysteine [right arrow] lanthionine
+ [H.sub.2]S 
Cavallini, "Specific method for the determination of 1,4-thiomorpholine3,5-dicarboxylic acid and its unsaturated analogue lanthionine
ketimine," Journal of Chromatography, vol.
But Yin Hessefort, Lubrizol Advanced Materials, pointed out that a typical hair relaxer treatment can cause a 50% reduction in tensile strength because it changes about one third of disulfide bonds to lanthionine