lanthanum carbonate

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lanthanum carbonate


Pharmacologic class: Phosphate binder

Therapeutic class: Renal and genitourinary agent

Pregnancy risk category C


Dissociates in acidic environment of upper GI tract to release lanthanum ions, which bind dietary phosphate released from food during digestion and inhibit phosphate absorption by forming highly insoluble lanthanum phosphate complexes


Tablets (chewable): 500 mg, 750 mg, 1,000 mg

Indications and dosages

To reduce serum phosphate level in patients with end-stage renal disease

Adults: Initially, 1,500 mg P.O. (chewed) daily in divided doses with meals; titrate every 2 to 3 weeks until serum phosphate falls to acceptable level.


• Bowel obstruction, ileus, or fecal impaction


Use cautiously in:

• acute peptic ulcer, Crohn's disease, ulcerative colitis

• pregnant or breastfeeding patients

• children (safety and efficacy not established).


• Give before meals; ensure that patient chews tablets completely before swallowing to reduce risk of serious adverse GI events.

Adverse reactions

CNS: headache

CV: hypotension

GI: nausea, vomiting, diarrhea, constipation, abdominal pain

Metabolic: hypercalcemia

Respiratory: bronchitis, rhinitis

Other: dialysis graft complication or occlusion


Drug-diagnostic tests. Serum calcium: increased

Patient monitoring

• Monitor serum calcium and phosphorus levels periodically.

Patient teaching

• Instruct patient to take drug with or immediately after meals and to chew tablets completely before swallowing.

• Advise patient to discuss any planned dietary changes with prescriber.

• Inform female patient with childbearing potential that drug isn't recommended during pregnancy.

• Instruct female patient to tell prescriber if she's breastfeeding.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

lanthanum carbonate

(lan-than-um) ,


(trade name)


Therapeutic: hypophosphatemics
Pharmacologic: phosphate binders
Pregnancy Category: C


Reduction of serum phosphate levels associated with end-stage renal disease.


Dissociates in the upper GI tract forming lanthanate ions, which form an insoluble complex with phosphate.

Therapeutic effects

Decreased serum phosphate levels.


Absorption: Negligible absorption.
Distribution: Stays within the GI tract.
Metabolism and Excretion: Eliminated almost entirely in feces.
Half-life: 53 hr (in plasma).

Time/action profile (effect on phosphate levels)

POunknown2–3 wkunknown


Contraindicated in: Bowel obstruction;Ileus;Fecal impaction; Obstetric: Congenital abnormalities noted in animal studies; Pediatric: Potential negative effect on developing bone.
Use Cautiously in: Patients with risk factors for bowel obstruction, including history of GI surgery, colon cancer, constipation, ileus, diabetes, or taking medications that cause constipation; Lactation: Safety not established.

Adverse Reactions/Side Effects


  • nausea (most frequent)
  • vomiting (most frequent)
  • diarrhea
  • fecal impaction
  • GI obstruction
  • ileus

Fluid and Electrolyte

  • hypocalcemia


Drug-Drug interaction

May ↓ abosrption of fluoroquinolones, tetracyclines, and levothyroxine ; administer at least 1 hr before or 3 hr after lanthanum carbonate.


Oral (Adults) 1500 mg/day in divided doses; may be titrated upward every 2–3 wk in increments of 750 mg/day up to 4500 mg/day (usual range 1500–3000 mg/day).


Chewable tablets: 500 mg, 750 mg, 1000 mg

Nursing implications

Nursing assessment

  • Assess patient for nausea and vomiting during therapy.
  • Lab Test Considerations: Monitor serum phosphate levels prior to and periodically during therapy.

Potential Nursing Diagnoses

Nausea (Side Effects)


  • Do not confuse lanthanum carbonate with lithium carbonate.
  • Divide total daily dose and administer with meals.
  • Oral: Administer with or immediately after meals. Tablets should be crushed or chewed completely before swallowing; intact tablets should not be swallowed.

Patient/Family Teaching

  • Instruct patient to take lanthanum as directed.

Evaluation/Desired Outcomes

  • Decrease in serum phosphate to below than 6.0 mg/dL in patients with end stage renal disease.
Drug Guide, © 2015 Farlex and Partners
References in periodicals archive ?
Fourteen out of the 21 patients were treated with lanthanum carbonate for 12 weeks.
Choose a diet that is low in phosphorous or that includes phosphate binders, such as aluminum hydroxide, calcium d carbonate, calcium acetate, sevalamar HC1, or lanthanum carbonate. Phosphate binders can be added if necessary.
Late last month Lupin rolled out lanthanum carbonate chewable tablets 500 mg (base), 750 mg (base), and 1,000 mg (base).
Figure 2 depicts the Raman spectrum of a PLD target synthesized using pure lanthanum carbonate [La.sub.2][(C[O.sub.3]).sub.3.sup.*] 6[H.sub.2]O.
These agents are often categorized into calcium-based (calcium acetate, calcium carbonate, and calcium citrate) and calcium-free binders (aluminum hydroxide, sevelamer hydrochloride, sevelamer carbonate, lanthanum carbonate, nicotinamide, and magnesium carbonate), all of which are effective in lowering serum phosphate (Malberti, 2013).
lanthanum carbonate or lanthanum carbonate or sevelamer carbonate sevelamer carbonate Increase First administer calcium First administer calcium the serum carbonate, then vitamin D3 carbonate, then vitamin D3 calcium Table 5.
He was first author on a study in which 148 patients with moderate CKD were randomized to 9 months of calcium acetate, sevelamer carbonate, lanthanum carbonate, or placebo.
Lanthanum carbonate and seve-lamer are indicated to reduce serum phosphate levels in patients with endstage renal disease.
Hence its foray into renal care with lanthanum carbonate tablets that it will jointly commercialise with Lupin.
The lawsuit was filed in response to an ANDA (Abbreviated New Drug Application) filed by Natco seeking FDA approval to market and sell generic versions of Shire's 500 mg, 750 mg, and 1 g FOSRENOL (Lanthanum Carbonate) products.
The newest phosphate binder is lanthanum carbonate, a rare earth element that has low solubility and minimal gastrointestinal absorption.