lanosterol


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la·nos·ter·ol

(la-nos'tēr-ol),
A zoosterol synthesized from squalene and a precursor to cholesterol.

lanosterol

one of the substances formed during the synthesis of cholesterol.
References in periodicals archive ?
Using lanosterol and other sterols as a clue, Gestwicki and his group assembled and tested 32 additional sterols, and eventually settled on one, which they call "compound 29," as the most likely candidate that would be sufficiently soluble to be used in cataract-dissolving eye drops.
Using lanosterol and other sterols as a clue, Gestwicki and his group assembled and tested 32 additional sterols, and eventually settled on one, which they call compound 29, as the most likely candidate that would be sufficiently soluble to be used in cataract-dissolving eye drops.
Incubating cataractous lenses from rabbits with lanosterol solution reduced the opacity of the tissue.
This was the case for desmosterol and 7-dehydrocholesterol, and sitosterol and lanosterol as well as the known interference from lathosterol and zymosterol.
Effect of lanosterol on the in vitro maturation in semi-defined culture system of prepubertal ewe oocytes.
Altered gene expression of hepatic lanosterol 14a-demethylase (CYP51) in lead nitrate-treated rats.
D degree from China Agricultural Unversity, Beijing in 2008 with thesis title of "The expression and regulation of lanosterol 14a-demethylase in mouse during folliculogenesis, embryo development and embryo implantation".
Several of the genes that were found by the microarray study to be more highly transcribed in androgen ablation-resistant tumors encoded biosynthetic enzymes involved in the synthesis of cholesterol, including HMG-CoA synthase, squalene synthase, lanosterol synthase, and squalene monooxygenase, the rate-limiting enzyme in sterol synthesis.
Voriconazole is a triazole antifungal that inhibits the cytochrome p450-dependent enzyme lanosterol 14 alpha-demethylase, thereby disrupting cell membrane synthesis.
Contrary to the general trend of suppression of CYP-450s as discussed above, lanosterol 14[alpha]-demethylase (CYP51), an essential enzyme for cholesterol biosynthesis, was found induced in Pb nitrate-mediated liver hyperplasia (25,26).
Like the other triazole antifungals, posaconazole inhibits the fungal enzyme lanosterol 14-alpha-demethylase (3-5).