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A zoosterol synthesized from squalene and a precursor to cholesterol.
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"Some existing drugs, initially made for people with high cholesterol, were designed to target lanosterol synthase--but they were never really thought of as cancer drugs.One of them is even more potent than MI-2, so we're now working with a team of chemical biologists to see if we can modify the drug so that it reaches the brain," he said.
Lanosterol reverses protein aggregation in cataracts.
The carboxyl groups on poly(IA) chains are intended to improve the water compatibility of the PU surface, and the imidazole groups worked as antifungal agents to block the function of lanosterol esterase.
It is the determination of the crystal structure of the CYP51 from the model yeast Saccharomyces cerevisiae in complex with its substrate lanosterol and with the triazole inhibitors fluconazole and itraconazole (16).
In the cholesterol synthetic pathway, the first cyclized sterol product derived from squalene is lanosterol which is catalyzed by oxidosqualene cyclase [101, 103].
Azoles inhibit fungal cytochrome P450-dependent 14[alpha]-demethylation of lanosterol, leading to substitution of methylated sterols in the membrane and depletion of ergosterol, which results in an accumulation of precursors with abnormalities in the fungal membrane.
Enzyme structure has sterol-sensing domain (SSD) and it is subjected to proteasome degradation if it binds oxysterols, lanosterol, 4,25-dihydrolanosterol but not cholesterol [80].
Transcriptional levels of genes for cholesterol biosynthesis, such as HMG-CoA reductase (Hmgcr), squalene epoxidase (Sqle), mevalonate (diphospho) decarboxylase (Mvd), and lanosterol synthase (Lss), were remarkably decreased in the HL group compared to the HU group (Figure 4(c)).
latifolia genome for potential triterpenoid biosynthesis genes and found a gene (Gglean006755.1) that encodes lanosterol synthase (LSS; K01852; EC:
Azole antifungals work by inhibiting the cytochrome P450 dependent enzyme lanosterol 14 alpha-demethylase, an enzyme necessary for the conversion of lanosterol to ergosterol, a vital component of the cell membrane in fungi.
Recently, researchers demonstrate that lanosterol, not cholesterol, plays a preventive role in cataract formation, inhibiting lens opacity, and reversing crystalline aggregation [14].
In BMM, IFN-[alpha] was associated with the downregulation of genes involved in mevalonate synthesis (HMGCS1, HMGCR), lanosterol synthesis (FDFT1, SQLE, and LSS) and cholesterol synthesis (CYP51, MSMO1, HSD17B7, and SC5D).