Role of A-type lamins in signaling, transcription, and chromatin organization.
Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.
Using an advanced array of techniques available in fruit fly studies, the team demonstrated that lamins were a necessary component of supporting niche organization, which in turn regulates proper proliferation and differentiation of germline stem cells in fruit fly testis.
These results could have implications for the role of lamins in other types of stem cell niches," Zheng said.
Lamins are classified as type A or B based on isoelectric point (Goldman et al.
Lamins, including lamins A/C, and lamin B1 are suppressed in colon cancer, suggesting their pathogenic role in colorectal carcinogenesis (Atreya and Neurath 2008).
Dephosphorylation of lamins is essential at the right event in the normal direction [21].
It consists mainly of intermediate filaments called lamins and microfilaments cal led act ins and DNA topoisomeraseII (Fig.
Lamins A and C, the products of the LMNA gene, ate nuclear intermediate filament proteins and are the major structural components of the lamina network that underlies and supports the nuclear envelope.
The "mechanical stress hypothesis" model suggests that the lamins and their associated proteins form a filamentous nucleoskeleton that supports the nuclear envelope (NE).
These disorders and their relationship to LMNA mutations have been reviewed recently {Burke and Stewart (2002)}, and Hutchinson (2002) has reviewed the function of
lamins in the nuclear envelope.
3 in humans and encodes the
lamin A/C proteins (Feng and Howard, 1993).
