As for RPSA, this laminin receptor
can promote metastasis by facilitating the cancer cell adhesion to the laminin component in the basement membrane (Nelson et al.
The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the [beta]1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67kDa laminin receptor
These integrins act as a laminin receptor
and mediate cell attachment to laminin (20).
Formation of the 67-kDa laminin receptor
by acylation of the precursor.
PIT resulted in reduced expression of Laminin receptor
1, Apolipoprotein E precursor (Apo-E) and Neuron specific gamma Enolase at 48h followed by significant increase at 96h after PIT.
The company's research is focused on the use of the oncofetal antigen ("OFA"), or more specifically, iLRP - immature Laminin Receptor
Protein, as a cancer immunogen (a cancer target against which the immune system is directed) found in many tumor cell lines or fetal tissue, but not found in normal mature tissue.
In this study EGCG was found to mediate the activity of the metastasis-associated 67-kDa laminin receptor
Meruelo suspects that the virus favors cancer cells because they carry a surface protein called the laminin receptor
A key attraction for outside researchers is that Quantum's exclusive licenses or patents cover the identification and use of Oncofetal Antigen - Immature Laminin Receptor
(OFA) to treat cancer, and the OFA protein has been found to be expressed on hundreds of various cancer lines.
In the NG-treated platelets, there were increase in the levels of growth factor receptor-bound protein 2 (Grb2), thrombospondin 1, tubulin alpha 6 and decrease in the levels of thioredoxin, Cu-Zn superoxide dismutase, DJ-1 protein, peroxiredoxin 3, thioredoxin-like protein 2, ribonuclease inhibitor, potassium channel subfamily V member 2, myosin regulatory light chain 9 and laminin receptor
20 SCIENCE, Martin and his co-workers reported that a synthetic compound mimicking part of the laminin structure can inhibit melanoma cell migration in mice and cell cultures -- most likely by competing with the basement membrane's laminin for the laminin receptor
on the cancer cells, and thus preventing the interaction between the cells and the basement membrane.
The Oncofetal Antigen - Immature Laminin Receptor
patents are a product of 20 years and $30 Million of research at The University of South Alabama Medical & Science Foundation and were primarily funded by the National Institute of Health's National Cancer Institute.