Laminin is coated onto CC to form effective connection and increase grafts cell density, for CECs express laminin receptor
and previous experimental study have proved that laminin can promote adhesion, migration, and moderate proliferation of cultured CECs., Levis et al . seeded CECs onto CC without coated laminin and reached a final graft cell density <2000 cells/mm 2, while in our study, laminin-coated CC can eventually got a graft cell density more than 3600 cells/mm 2.
As for RPSA, this laminin receptor
can promote metastasis by facilitating the cancer cell adhesion to the laminin component in the basement membrane (Nelson et al.
Davoli et al., "Localization of Lutheran, a novel laminin receptor
, in normal, knockout, and transgenic mice suggests an interaction with laminin [alpha]5 in vivo," Developmental Dynamics, vol.
The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the [beta]1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67kDa laminin receptor
. In this study, we identified a novel function of the YIGSR peptide to enhance collagen synthesis in human dermal fibroblasts.
These integrins act as a laminin receptor
and mediate cell attachment to laminin (20).
Formation of the 67-kDa laminin receptor
by acylation of the precursor.
PIT resulted in reduced expression of Laminin receptor
1, Apolipoprotein E precursor (Apo-E) and Neuron specific gamma Enolase at 48h followed by significant increase at 96h after PIT.
The company's research is focused on the use of the oncofetal antigen ("OFA"), or more specifically, iLRP - immature Laminin Receptor
Protein, as a cancer immunogen (a cancer target against which the immune system is directed) found in many tumor cell lines or fetal tissue, but not found in normal mature tissue.
In this study EGCG was found to mediate the activity of the metastasis-associated 67-kDa laminin receptor
Meruelo suspects that the virus favors cancer cells because they carry a surface protein called the laminin receptor
. Normal cells harbor this receptor, too, but it's usually occupied by the protein laminin.
The laminin receptor
, integrin [alpha]6[beta]1, regulates tumor cells survival and promotes EC growth in GBM  and is required for GSCs maintenance [80, 81].
In the NG-treated platelets, there were increase in the levels of growth factor receptor-bound protein 2 (Grb2), thrombospondin 1, tubulin alpha 6 and decrease in the levels of thioredoxin, Cu-Zn superoxide dismutase, DJ-1 protein, peroxiredoxin 3, thioredoxin-like protein 2, ribonuclease inhibitor, potassium channel subfamily V member 2, myosin regulatory light chain 9 and laminin receptor