laminin 5


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Related to laminin 5: LAMA5

laminin 5

A complex glycoprotein composed of three subunits (alpha, beta and gamma), which is involved in:
• Cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes;
• Signal transduction via tyrosine phosphorylation of pp125-FAK and p80; and
• Keratinocytes differentiation.
References in periodicals archive ?
Immunokimyasal tetkiklerle SP'de saptanmis olan baslica antijenler laminin 5, BP180 ve [beta]4 intergrin subunitesidir.
Otoantikorlarla baglanma sonrasi tip VII kollajen molekulunun dimer yapisinin engellendigi veya laminin 5 ve fibronektin gibi ligandlariyla iliskisinin bozuldugu dusunulmektedir (1).
Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the alpha subunit of laminin 5.
Genel bilgilerde bahsedildigi gibi otoimmun bulloz hastaliklarin immunopatogenezinin arastirilmasi amaciyla (ornegin envoplakin, periplakin, kollajen VII, laminin 5, vb.