LMNB1

(redirected from lamin B1)

LMNB1

A gene on chromosome 5q23.2 that encodes lamin B1, a protein highly conserved in evolution that forms part of the two-dimensional matrix of proteins located next to the inner nuclear membrane. Lamins are involved in providing nuclear stability and chromatin structure, and in gene expression.

Molecular pathology
LMNB1 mutations cause autosomal dominant adult-onset leukodystrophy (ADLD).
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References in periodicals archive ?
Lamin B1 is required for mouse development and nuclear integrity.
Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis.
miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination.
The primary antibodies for Bax, Bcl-2, GAPDH, and Lamin B1 were obtained from Proteintech (Wuhan, China).
After blocking with 5% nonfat milk, the membranes were incubated with Bax (1:500), Bcl-2 (1:500), cleaved caspase-3 (1:1000), cleaved PARP (1: 1000), p65 (1: 1000), GAPDH (1: 1000), and Lamin B1 (1: 500) antibodies overnight at 4[degrees]C.
These include the nucleus (tagged by the protein lamin B1), mitochondria (Tom20), microtubules (alpha-tubulin), cell-to-cell junctions (desmoplakin) and adhesion (paxillin).
Tenders are invited for Supply Of Primary And Secondary Antibodies See As Per The Annexure Anti- Lamin B1 (Zl-5)), Mouse Monoclonal Ig, Unlabelled Antibody, Concentration = 200 Ug /Ml
[beta]-Asarone appeared to increase expression of lamin B1. p53.
Lamin B1 is depressed in primary human and murine cell lines when they undergo senescence after DNA damage, replicative exhaustion, or oncogene expression (Shimi et al.
Consistent with the increased gene expression of these apoptosis-inducing factors (Figure 2(a)), cleavage of the caspase substrate Lamin B1 [36-40] was also increased by doxorubicin treatment in a substrate rigidity-dependent manner (Figure 2(b)).
(b) Total cell lysates were subjected to immunoblot analysis with antibodies against p21, Lamin B1, and [alpha]-tubulin as a loading control.
To this end, I will perform replication-timing and chromosome-conformation studies using mouse models which allows me to conditionally delete genes encoding for key regulator of nuclear structure, such as cohesin (Rad21) and Lamin B1. I aim with this proposal to advance the understanding of how spatial organization of chromatin regulates and integrates different nuclear functions, with a specific focus on DNA replication.