Older term for prolactin-producing.
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The results of azocarmine and orange G staining could demonstrate the difference of two types of acidophil cells: Orange somatotropic cells and nacarat lactotrophic cells (Figs.
The secretion of prolactin is predominantly regulated by dopaminergic inhibition and this mechanism could be blunted in patients on RRT, also called lactotrophic resistance [2-4].
In addition to the reduced renal clearance of prolactin, lactotrophic resistance is a major cause of hyperprolactinemia in patients on RRT.
It is produced by lactotrophic cells of the anterior pituitary.
These drugs block the dopamine 2 receptors (D2R) in the central nervous system which induces an increase of PRL synthesis in lactotrophic cells of the anterior pituitary [20-22].
The TRH molecule binds to its receptor in the lactotrophic cells triggering the activation of PLC and increasing the formation of diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3).
The second route inhibits the pathway activated by D2R dopamine receptor, stimulating PRL production and proliferation of lactotrophic cells by increasing cAMP ending in PKA phosphorylation pathways that trigger PRL gene expression [107] (Figure 7).
Morphometrical and ultrastructural analyses of hypophyseal cells from adult monkeys fed a protein-restricted diet containing 10% protein have shown a decline in the number of somatotrophic, lactotrophic, gonadotrophic and tireotrophic cells.