pituitary adenomas, also called prolactinomas, account for almost half of non-physiologic hyperprolactinemia.
The center part of the pars distalis: pars distalis (PaD), acidophilic cell (AC), basophilic cell (BC), chromophobe cell (CC), sinusoid (Sin), somatotroph cell (SC), lactotroph
Dr Ahmad explained: "Hyperprolactinemia is a condition in which a person has higher-than-normal levels of the hormone prolactin in the blood, produced in the lactotroph
cells of the anterior pituitary gland.
In conclusion, PROP1 gene has maintenance role in five types of principal anterior pituitary hormone-secreting cells, which are somatotroph, lactotroph
, thyrotroph, gonadotroph, and corticotroph, basis, and their differentiation progress.
It is secreted by glandular cells (lactotroph
cells) from the anterior pituitary gland (AP).
As the gland expands, there is a simultaneous increase in the size and population of lactotroph
cells and a progressive increase in serum prolactin (Imran, Ur, & Clarke, 2007).
Dopamine stimulates [D.sub.2] receptors located on the surface of the lactotroph
pituitary cells and provokes a tonic suppression on prolactin secretion.
During pregnancy, estrogen-stimulated lactotroph
hyperplasia leads to a progressive increase in serum PRL and a 10-fold increase at term.
(5,9) GHRH induced acromegaly exhibits mild hyperprolactinemia due to hyperstimulation of pituitary lactotroph
cells by GHRH, as seen in human GHRH transgenic mice.
(2) The endocrine manifestations and aggressivity of pituitary adenomas are usually correlated with specific morphologic phenotypes.32 Generally, aggressive behavior is a phenomenon of clinically silent hormone-containing adenomas and unusual plurihormonal adenomas as well as the rare lactotroph
adenoma with GH immunoreactivity, known as the "acidophil stem cell adenoma." Additional information, such as tumor size, radiologic, gross, or microscopic evidence of invasion, and the proliferative activity level of a tumor as identified by immunohistochemical proliferation markers, can be incorporated in a multidisciplinary fashion to determine the optimal therapeutic approach to management of the individual patient.
Preservation of lactotroph
function or presence of hyperprolactinemia is exceedingly rare and have been reported before the availability of modern imaging tools as magnetic resonance imaging (MRI) (6).