LCT

(redirected from lactase-phlorizin hydrolase)

LCT

A gene on chromosome 2q21 that encodes lactase, a glycosyl hydrolase integral to the plasma membrane, which has activity of both phlorizin hydrolase and lactase.
 
Molecular pathology
Defects of LCT cause congenital lactase deficiency.
References in periodicals archive ?
Correlation between lactose absorption and the C/T-13910 and G/A-22018 mutations of the lactase-phlorizin hydrolase (LCT) gene in adult-type hypolactasia.
Correlation between lactose absorption and the C/T 13910 and G/A -22018 mutations of the lactase-phlorizin hydrolase (LCT) gene in adult-type hypolactasia.
Deficiency of the brush border enzyme lactase-phlorizin hydrolase (LPH), which catalyzes the hydrolysis of lactose to yield glucose and galactose, leads to malabsorption of lactose and to lactose intolerance when unabsorbed lactose reaches the colon and is fermented by bacteria (1, 2).