lactase persistence


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lac·tase per·sis·tence

an inherited trait (autosomal dominant) in which the levels of lactase do not decline after weaning. Compare: lactase restriction.
References in periodicals archive ?
The genetic variant of lactase persistence C(-13910)T as a risk factor for type I and II diabetes in the Finnish population.
European lactase persistence genotype shows evidence of association with increase in body mass index.
Individuals with either T-13910 or G-13915 allele (lactase persistence) had significantly lower breath [H.sub.2] peak (Average: 8 and 10 ppm, respectively) compared to the C/C-13910 and T/T-13915 (Average: 121 ppm).
In this study, several mutations and/or variants (C/G-13907, C/T-13910, T/C-13913, T/G-13915, G/C-14010, G/A-22018, and T/C-3712) were evaluated and tested against lactase persistence. Of these SNPs, only two (C/T-13910 and T/G-13915) seemed to be associated with lactase persistence among Omani individuals.
* Natural selection: lactase persistence may have been selected for in some human populations after the advent of animal husbandry;
* Regulation of gene expression: the lactase persistence mutation occurs in a regulatory sequence;
(6), studied a cohort of 196 non-related individuals of finnish origin, reporting a 100% correlation of the lactase persistence phenotype with the presence of allele T of a SNP located 13910 bp upstream of the lactase gene.
A high correlation between T-13910, A-22018 and the lactase persistence phenotype has also been reported in a Brazilian population of Caucasian descent7 and many European countries (8-10).
As lactase persistence is a dominantly inherited genetic trait, we examined the genetic association primarily under a dominant model (CC vs CT + TT).
Furthermore, the associations of rs4988235 with lactase persistence and milk intake vary across populations.
Oddny Sverrisdottir, an evolutionary biologist at the University of Uppsala in Sweden said that throughout the years, she has heard so many evolutionary hypotheses about lactase persistence because they are so fun to coin.