lactamase


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β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

lactamase

beta lactamase A bacterial enzyme capable of breaking down the beta lactam ring of certain antibiotics, including penicillins, inactivating them
References in periodicals archive ?
Phenotypic tests have been developed for the recognition of ESBLs carrying strains.16 There are no CLSI approved protocols to identify Amp C [beta] lactamase enzymes.7 Boronic acid compounds are considered as reversible inhibitors of Amp C [beta] lactamase enzymes.9 Many studies have confirmed the use of boronic acid as a simple, highly sensitive, specific and practical method to detect Amp C [beta] lactamases among Gram negative bacteria.10-12 There are many reports in which Escherichia coli and Klebsiella pneumoniae have carried both ESBLs and Amp C enzymes.10,13
Frequency and sensitivity pattern of extended spectrum beta lactamase producing isolates in a tertiary care hospital laboratory of Pakistan.
Survey beta lactamase production and resistance pattern into beta lactame antibiotics in Bacillus cereus strain isolated from staff hands and hospital environment in Iran.
Table I: Prevalence of the antibiotic resistance and beta lactamase production among 22 clinical K.
Empirical treatment of nosocomial UTIs consists of examination of bacterial spectrum and antibiotics sensitivity testing.1 All over the world, resistance against beta-lactam antibiotics is increasing due to Extended Spectrum Beta Lactamases (ESBLs) and Amp-c beta-lactamase production.
Out of these 33 Amp C positive isolates, 19 had shown presence of Amp C beta lactamase alone, while 14 isolates were co-producers i.e presence of Amp C beta lactamases along with ESBLs (Extended spectrum beta lactamases).
Ratios of cefotetan versus cefotetan/cloxacillin of e"8 were considered positive for AmpC beta lactamase production.
The subject of this study was survey prevalence Beta lactamase enzyme in Staphylococcus species isolated of foods In Isfahan city in Iran.
Introduction: Urinary tract infections (UTIs) caused by extended spectrum beta lactamase (ESBL) producing bacteria have become a growing problem due to emerging antibiotic resistance.