MFGE8

(redirected from lactadherin)

MFGE8

A gene on chromosome 15q25 that encodes medin (milk fat globule-EGF factor 8 protein), which plays a key role in maintaining epithelial homeostasis and in promoting mucosal healing. Medin promotes VEGF-dependent neovascularisation, helps remove apoptotosed cells, binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner and binds rotavirus, inhibiting its replication.
References in periodicals archive ?
Tait, "Transmembrane voltage regulates binding of annexin V and lactadherin to cells with exposed phosphatidylserine," BMC Biochemistry, vol.
Lactadherin binds to elastin--a starting point for medin amyloid formation?
It now appears that a constituent of breast milk, lactadherin, has an anti-rotavirus activity.
The researchers also took samples of the mothers' breast-milk, measuring the lactadherin levels.
The rotavirus mistakenly identifies lactadherin as this home-grown carbohydrate and latches onto it in order to anchor itself in the gut.
Breast milk consumed by the asymptomatic infants had higher quantities of lactadherin, indicating that the carbohydrate effectively suppresses the symptoms of viral infection and that some women make more of it than others.
OTCBB:SMPM), a cancer stem cell company focused on in-licensing differentiated oncology compounds and anti-cancer agents, will present preclinical data on Angiolix, a humanized monoclonal antibody, that recognizes a migrating adhesion molecule called Lactadherin, at the academic community sponsored Stem Cells and Cancer conference March 2-7 in Keystone, Colorado.
Somanta's recent data suggests that tumor cells express Lactadherin and that Angiolix may be able to act to specifically target breast cancer stem cell and cause tumor regression by blocking the growth of tumor vasculature by its ability to neutralize Lactadherin-integrin receptor binding.
Subsequently, MVs were labeled by adding 10 [micro]L fluorescein isothiocyanate(FITC-) conjugated Lactadherin (83 [micro]g [mL.
Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol," Apoptosis, vol.