MFGE8

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MFGE8

A gene on chromosome 15q25 that encodes medin (milk fat globule-EGF factor 8 protein), which plays a key role in maintaining epithelial homeostasis and in promoting mucosal healing. Medin promotes VEGF-dependent neovascularisation, helps remove apoptotosed cells, binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner and binds rotavirus, inhibiting its replication.
References in periodicals archive ?
We considered including calcein acetoxymethyl ester (calcein AM), calcein acetoxymethyl ester violet (calcein violet), carboxyfluorescein succinimidyl ester (CFDA-SE, here and commonly referred to as CFSE), 4-(2-[6-(dioctylamino)-2-naphthalenyl]ethenyl)-1(3-sulfopropyl)pyridinium (di-8-ANEPPS), annexin V, lactadherin, and Paul Karl Horan 67 (PKH67) (8, 9, 11-15).
The third way is to fuse the exogenous proteins with lipid-binding C1C2 domains of the human lactadherin protein (MFGE8) noncovalently [85, 87, 88] (Figure 2(a)).
(c) MVs were defined as phosphatidylserine expressing (PS+) particles based on their ability to bind lactadherin within the 0.1-1.0 [micro]m gate.
Tait, "Transmembrane voltage regulates binding of annexin V and lactadherin to cells with exposed phosphatidylserine," BMC Biochemistry, vol.
Lactadherin binds to elastin--a starting point for medin amyloid formation?
It now appears that a constituent of breast milk, lactadherin, has an anti-rotavirus activity.
The compound, called lactadherin, is manufactured in the breast and doesn't break down in the baby's stomach.
Opsonins include antibodies, complement, fibronectin, mannose-binding lectin, and milk fat globulin (lactadherin) [3].
Subsequently, MVs were labeled by adding 10 [micro]L fluorescein isothiocyanate(FITC-) conjugated Lactadherin (83 [micro]g [mL.sup.-1], Haematologic Technologies Inc., Vermont, USA) [29, 30], characterized by a phosphatidylserine- (PS-) bonding motif [29, 30].
Gluc is a reporter protein that emits bioluminescence when its substrate, coelenterazine, is present, and lactadherin is a membrane-associated protein mainly found in exosomes.
Cai et al., "Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol," Apoptosis, vol.