An ideal lacrimomimetic must provide an environment compatible with the maintenance of the ocular physiology and must support epithelial healing (UBELS et al.
Lacrimomimetics are only prescribed as an adjunct until normal tear production is restored (GRAHN & STOREY, 0004).
Given the variety of available products, the aim of this review was to present the main formulations of lacrimomimetics and their effect on the ocular surface, and thus guide clinicians on the best choice for each individual patient.
Furthermore, the formulations of lacrimomimetics must accommodate the necessity of intermittent instillation, while aiming to mimic the continual production of natural tears (DOGRU et al.
Lacrimomimetics usually have a neutral to mildly alkaline pH (HOPKINS, 2007).
The appropriate lacrimomimetic should be selected based on the nature of the deficiency and should be used as adjuvant therapy to lacrimostimulants until the latter restore normal tear production.
Treatment basically consists of the application of lacrimomimetics, anti-inflammatory agents (except in the presence of ulcerative keratitis), and mainly lacrimostimulants such as cyclosporin A (ANDRADE & LAUS, 1997; GRAHN & STOREY, 2004).