For patients with ipsilateral DEH, labyrinthectomy
has proved to be curative.
Those that destroy hearing are labyrinthectomy
and translabyrinthine nerve section.
Most otologists agree that the traditional surgical approaches for the management of unilateral Meniere's disease, such as vestibular neurectomy and labyrinthectomy
, are contraindicated in bilateral Meniere's s disease because of the risk of hearing loss, disequilibrium, and oscillopsia.
Approximately 12% of patients reported that their last treatment was destructive therapy, such as chemical labyrinthectomy
with intratympanic gentamicin or vestibular neurectomy.
Lasker, "Unidirectional rotations produce asymmetric changes in horizontal VOR gain before and after unilateral labyrinthectomy
in macaques," Experimental Brain Research, vol.
Another procedure, a labyrinthectomy
, calls for removing the balance portion of the inner ear; however, this removes both the balance and hearing function from the affected ear, and is performed only if the patient already has near-total or total hearing loss in that ear.
Successful electrode insertion has been achieved by drilling out the obliterated portion of the basal turn (2) or by performing a partial labyrinthectomy
to gain access to the round window and allow electrode insertion (7).
Surgical intervention--including installation of an endolymphatic shunt, labyrinthectomy
, or vestibular neurectomy (16) --or transtympanic injections of gentamicin (17) are options in severe cases.
in patients with severe Meniere's disease uncontrolled by drugs and lifestyle changes and where hearing is no longer adequate, a labyrinthectomy
has a 95 per cent success rate in eliminating major spells.
, the removal of the membranous labyrinth, is an irreversible procedure that is often successful in eliminating the dizziness associated with Meniere's disease.
and eighth nerve section are procedures in which the balance and hearing mechanism in the inner ear are destroyed on one side.
The mRNA expression of UCP3, UCP4, and especially UCP2 is upregulated after a unilateral labyrinthectomy
in the inner ear of rats.