l-gulonolactone oxidase


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l-gu·lon·o·lac·tone ox·i·dase

the enzyme that catalyzes the conversion of l-gulonolactone and O2 to H2O2 and l-xylo-hexulonolactone, a precursor of ascorbic acid; absent in humans.
References in periodicals archive ?
Effect of dietary fluoride on L-gulonolactone oxidase activity and tissue ascorbic acid (Vitamin C) concentration.
However, a defective gene for the enzyme L-gulonolactone oxidase, required in the last steps of vitamin C synthesis, is lacking in humans (and a few other mammals), resulting in inability of the entire human population to synthesize vitamin C.
The objective of this study was to see if supplementation lowered the activity of the enzyme which catalyzes the synthesis of ascorbic acid in the glucose/xylose cycle, L-gulonolactone oxidase (EC 1.1.3.8; L-gulono-[gamma]-lactone:oxidoreductase GLO).