l-asparaginase


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Related to l-asparaginase: methotrexate, cyclophosphamide, etoposide, vincristine

l-asparaginase

Oncology A chemotherapeutic used for lymphomas and lymphocytic leukemia Adverse effects Vomiting, hepatic dysfunction, allergic reaction, lethargy
References in periodicals archive ?
I: L-asparaginase treated rats with diclofenac sodium treated rats, showed mild inflammatory cells infiltration
L-Asparaginase (EC 3.5.1.1) belongs to a group of homologous amidohydrolases family, which catalyses the hydrolysis of amino acid L-asparagine to L- aspartate and ammonia [1].
(5) To our knowledge, lomustine use has not been reported in avian species, and only one case of L-asparaginase being used has been reported, with a survival time of 8 weeks.
Preliminary Screening of Endophytic Fungi for L-Asparaginase Activity.
The present investigation deals with isolation and characterization of L-asparaginase from river sediment isolates of actinomycetes as a novel source of enzyme which is effective against leukemia.
This could be explained based on the differences in induction and consolidation courses, between the 2 protocols since pediatrics protocol has double doses of L-asparaginase and it was repeated in higher doses in all 9 phases of consolidation in pediatrics protocol.
At present, L-asparaginase is available in the market with different brand names, such as ERWINASE, CLOLAR, LEUKINE, ONCASPAR, ARR-ANON, KIDROLASE and ELSPAR.
For quantitative estimation of L-asparaginase, the modified Czapek Dox broth (mentioned before) (17) was used as the production medium.
Low levels of AT may be found with the use of heparin, hepatic disease, nephrotic syndrome, hemodilution, and after use of L-asparaginase and in disseminated intravascular coagulation (DIC) syndrome.
In 2017, the company saw positive results from a Phase 2b study of eryaspase (L-asparaginase encapsulated in red blood cells) in metastatic pancreatic cancer.
Further, metastasis was found greatly limited by reducing asparagine synthetase, treatment with the chemotherapy drug L-asparaginase, or dietary restriction.