Kynurenic acid (KYNA), an endogenous glutamate-receptor antagonist preferentially blocking NMDA-receptors, has analgesic properties and has also been implicated in the pathophysiology of schizophrenia.
Our results show that DS inhibits hepatic TDO enzyme activity following chronic treatment, whilst augments brain IDO activity following both acute and chronic administration, that may result in the production of brain kynurenic acid and/or neuro-toxic metabolite, quinolinic acid therefore there is a need that effects of DS on kynurenine pathway should be further investigated to rule out the protective effect of DS in inflammation-induced depression and AD.
attenuates MPP--induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway.
Both serotonin and kynurenic acid
are metabolites of tryptophan, an essential amino acid that C.
We believe that interventions aimed specifically at reducing the level of kynurenic acid in the brain are a promising strategy for cognitive improvement in both healthy patients and in those suffering from a variety of brain diseases ranging from schizophrenia to Alzheimer's disease," says Dr.
Kynurenic acid is a substance with unique biological properties and is produced when the brain metabolizes the amino acid L-tryptophan.
2006-2007) Facilitated beam-walking recovery during acute phase by kynurenic acid
treatment in a rat model of photochemically induced thrombosis causing focal cerebral ischemia.
Effects of kynurenic acid as a glutamate receptor antagonist in the guinea pig.
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Bruno said that kynurenic acid
is present in all human brains and has some useful functions, but excessive amounts of this compound may interfere with other chemical processes that govern the ability to pay attention and think strategically under changing conditions.
In addition, there is increasing evidence that an imbalance in the levels of kynurenic acid
, a natural neuromodulator in the brain, is associated with schizophrenia.
Neuropharmacology of quinolinic and kynurenic acids