kuru


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prion

 [pri´on]
any of several pathogenic, transmissible forms of the core of prion protein that cause a group of degenerative diseases of the nervous system known as prion diseases. Prions have a structure different from that of normal prion protein, lack detectable nucleic acid, and do not elicit an immune response.
prion disease any of a group of fatal degenerative diseases of the nervous system caused by abnormalities in the metabolism of prion protein. These diseases are unique in that they may be transmitted genetically as an autosomal dominant trait, or by infection with abnormal forms of the protein (prions). Inherited forms result from mutations in the gene that codes for prion protein; such mutations may also occur sporadically. Hereditary forms include some forms of Creutzfeldt-Jakob disease, Gerstmann-Sträussler syndrome, and fatal familial insomnia. Infectious forms of the disease result from ingestion of infected tissue or the introduction of infected tissue into the body (kuru and some forms of Creutzfeldt-Jakob disease). The latter has occasionally occurred during surgical procedures; it has also occurred as the result of injection of human growth hormone prepared from infected pituitary glands. Prion diseases also occur in animals. Called also transmissible neurodegenerative disease and subacute spongiform or transmissible spongiform encephalopathy.

ku·ru

(kū'rū), [MIM*245300]
A progressive fatal spongiform encephalopathy characterized by ataxia, tremors, lack of coordination, and death. Pathologic lesions in the brain include neuronal loss, astrocytosis, and status spongiosus. Found only in the Fore people in the highlands of New Guinea and transmitted through ritual cannibalism. It was initially attributed to a "slow virus" now known to be caused by prions. See: prion.
[native dialect, to shiver from fear or cold]

kuru

(ko͝or′o͞o)
n.
A fatal degenerative disease of the brain caused by a prion, formerly found among certain peoples of New Guinea and transmitted by the consumption of human flesh during mortuary rites.
A subacute spongiform encephalopathy, caused by a prion which, in its heyday, killed 90% of women in the once cannibalistic Fore tribe of New Guinea—women were most affected as they prepared and ate infected brains

ku·ru

(kū'rū)
A progressive, fatal form of spongiform encephalopathy, endemic in New Guinea and caused by prions. Transmission is believed to occur through ritual cannibalism.
See: prion
[native dialect, to shiver from fear or cold]

kuru

A slow, fatal spongiform encephalopathy that appeared to be limited to natives of the highlands of Papua New Guinea among whom it was spread by the practice of eating the brains of dead relatives. The disease is caused by a PRION, apparently, transmitted through skin abrasions during the preparation of the meal. This explained why kuru affected the women only. The prion is resistant to most of the normal methods of sterilization. The condition features headache, aching joints and limbs, progressive inability to walk and, later, even to sit up, inability to speak and to swallow, sometimes DEMENTIA and eventual death. Research on the Fore tribe in Papua, published in 2006, suggests that the incubation period of vCJD, while averaging 12 years, could be as long as 50 years. See also CREUTZFELDT-JAKOB DISEASE and BOVINE SPONGIFORM ENCEPHALOPATHY.

Kuru,

New Guinean word meaning "trembling with fear."
Kuru disease - fatal neurologic disease which existed in Fore tribe in New Guinea, perpetuated by cannibalism until the practice was abolished.
References in periodicals archive ?
(20) Biz ise hastaliga ait hicbir parametre (hastalik suresi, diyalize girme suresi, serum Ca, fosfor, ure, kreatinin ve toplam protein seviyesi) ile kuru goz arasinda iliski bulmadik.
Coventry City Council appointed a solicitor to investigate the behaviour of Coun Jaswant Singh Birdi after a Telegraph report in January which revealed police had been called to the Quick Shop store, in Harnall Lane East, Hillfields, following a heated exchange between the councillor and shop owner Raj Kuru.
Anderson's book is not an obituary and he need not be faulted for not having written it with the fondness characteristic of the genre, but conducting instead a scholarly appraisal of the scientific investigation of kuru and of the man most famously associated with it.
According to Kuru, 'The people complaining are those people that do not want to meet their obligations.'
His recent comments regarding swimming pools and alcohol-free restaurants were also aimed toward capturing undecided right-wing voters, added Kuru.
Also, he said they consulted their sponsors and donors, as well as former vice president, Dr Ponatshego Kedikilwe, the patron of Kuru Development Trust.
Testin tamamlanmasindan sonra sut yag, protein, laktoz, toplam kuru madde, yagsiz kuru madde oranlari ile donma noktasinin tespiti icin sut ornekleri alinmasi islemine gecilmistir.
Ahmed Kuru's appointment as managing director and CEO of the 'bad bank', the Asset Management Corporation of Nigeria (AMCON), in mid August 2015 was a surprise to some pundits.
Ending cannibalism stopped a deadly brain-wasting disease called kuru. But evolution had already devised a cure for the prion disease, a new study shows.
(6) ise deneysel kuru goz yaptiklari fare modelinde topikal infliksimab tedavisinin gozyasi uretimini ve konjonktivadaki goblet hucre sayisini arttirdigini, okuler yuzeydeki inflamatuvar hucreleri ve sitokinleri azalttigini gostermistir.