Caption: Figure 3: Conspicuous koilocytotic atypia
present throughout the tumor (H&E, x400).
The histology of flat condylomas shows acanthotic epithelium with mildly attenuated rete pegs, dyskeratosis, and koilocytotic atypia
in superficial cells.
Low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia 1 (LSIL/CIN 1) is characterized by koilocytotic atypia
, nuclear enlargement, hyperchromasia, and perinuclear cytoplasmic clearing.
In peri- and post-menopausal women, squamous atypia are often mistakenly classified as koilocytotic atypia
but when evaluated by polymerase-chain-reaction analysis, these findings have been shown not to be associated with the human papillomavirus (HPV).
Unusual patterns of squamous epithelium of the uterine cervix and pathologic study of koilocytotic atypia
. Ann NY Acad Sci.
The endocervical margins were normal and free of disease, but minor koilocytotic atypia
cytolgic changes were noted along the ectocervical margin.
Previously, evidence of a human papillomarvirus (HPV) infection without dysplasia was reported as koilocytotic atypia
. Atypical cytologic findings consistent with HPV infections are associated with a higher risk of progression to CIN. Under the current Bethesda System, similar cytology findings are now reported as low-grade squamous intraepithelial lesions (SIL).
The majority of studies reporting non-detection rates of CIN, however, included all cases of atypia, including koilocytotic atypia
. Under the Bethesda System, women with koilocytotic atypia
would be reclassified as having SIL.
([Dagger])Cellular changes of human papillomavirus (HPV)-- previously termed koi locytosis, koilocytotic atypia
, or condylomatous atypia--are included in the category of low grade squamous intraepithelial lesio n.
No significant association was detected between Papanicolaou smear classification and the presence of C trachomatis despite a relatively high rate of koilocytotic atypia