Aside from koilocytosis
, cytologic atypia is absent (Figure 2, B).
(8) found 81.1% of condylomata acuminata were positive for HPV DNA using in situ hybridization and koilocytosis
was the most powerful predictor of HPV-positivity with a risk ratio of 3.7.
Histologically, the tumor appears benign with papillomatosis, epithelial hyperplasia, and koilocytosis
, but clinically it can behave aggressively with extensive infiltration.
observed in verruca vulgaris is important in the histopathological differentiation between verruca vulgaris and simple keratosis.
and acanthosis of cervix established human papillomavirus infection.
: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins.
The diagnosis is typically made by histological features of hyperkeratosis, arborescent papillomatosis, acanthosis, and prominent koilocytosis
with nuclear pleomorphism .
Chronic nonspecific cervicitis was associated with other histological changes such as squamous metaplasia, koilocytosis
, epidermidization, and nabothian cyst.
The papillomatous projections making up the verrucoid lesion generally show a parakerototic surface with marked underlying acanthosis.5 Koilocytosis
of upper level epithelial cells is usually found.
That's because the cause of cervical cancer (infection with HPV) usually does not produce CIN 3 or cancer, and the cell changes that it does produce most often (atypia and koilocytosis
) are very common.
The typical exophytic CA is recognized by acanthosis, papillomatosis, hyperkeratosis, and viral cytopathic effects (koilocytosis
) in the upper epithelial cell layer.
HPV can only be reliably detected by DNA based tests since morphological changes on cytology such as koilocytosis
are not specific for oncogenic HPVs.