and acanthosis of cervix established human papillomavirus infection.
Chronic nonspecific cervicitis was associated with other histological changes such as squamous metaplasia, koilocytosis
, epidermidization, and nabothian cyst.
of upper level epithelial cells is usually found.
HPV can only be reliably detected by DNA based tests since morphological changes on cytology such as koilocytosis
are not specific for oncogenic HPVs.
A questionable aspect of TBS is the inclusion of koilocytosis
within the category of low grade-squamous intraepithelial lesion (LSIL) to indicate cellular changes associated with HPV infection (9).
Diagnosis Normal, CIN I, HPV status missing, n n (a) n Histopathology RDBH /MS 0 34 36 RDBH /MS 0 49 14 RDBH /MS 0 0 0 RDBH /MS 0 2 2 Cytology RDBH /MS 7 21 11 RDBH /MS 6 187 5 RDBH /MS 0 0 0 RDBH /MS 0 1 1 CIN II, CIN III, Cancer, HPV status n n n Histopathology RDBH /MS 42 59 3 (b) RDBH /MS 8 2 0 RDBH /MS 0 0 0 RDBH /MS 0 1 1 (c) Cytology RDBH /MS 5 2 0 RDBH /MS 3 0 0 RDBH /MS 0 0 0 RDBH /MS 0 0 0 (a) Including the cytologic diagnosis koilocytosis
("signs of HPV infection").
(wrinkled, hyperchromatic nuclei surrounded by a cleared halo in cells with a well-defined cell border) is characteristic of SP (figure, B).
The microsection of the skin of the animal group treated with bleomycin after exposure to UV B radiation for 20 days shows focal koilocytosis
in epidermis and mild fibrosis was seen in dermis.
93%) cases show koilocytosis
suggestive of HPV infection.
of Percentage cases Normal smear 8 4 Inflammatory 152 76 Dysplasia 26 13 Koilocytosis
12 6 Positive for 2 1 malignancy Table-9: Colposcopy Findings in study Appearance No.
Regardless of location or associated HPV type, these lesions are typically lined by an acanthotic squamous epithelium with other obvious changes associated with verrucous lesions, which include hypergranulosis, with large, dense, coalescing keratohyaline granules, and occasional koilocytosis
In a large study of "see and treat" visits, however, 27% of specimens either were normal or showed only koilocytosis