knockout


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knock·out

, knock-out (nok'out, nok'-out),
A genetically engineered organism in which the genome has been altered by site-directed recombination so that a gene is deleted.

knockout

(nŏk′out′)
adj. also knock-out (nŏk′out′)
Genetics Having a specific single gene inactivated or removed by genetic manipulation: knockout mice used in an experiment.
Experimental biology A genetically engineered mutant animal—e.g., Drosophila, mouse, fish, et al—in which a targeted gene has been inactivated to facilitate analysis of the knocked-out gene’s activity and function
Molecular medicine adjective Referring to the inactivation of a specific gene or genes noun A lab organism—e.g., yeast or mouse—in which a specific gene is altered, inactivating it and creating a model for a particular disease; in knockouts, an extracellular signal is converted to a functional intracellular change
Sports medicine KO The vanquishing of an opponent in a combat sport by bringing the opponent to the mat or ground. In boxing, this is defined as when the boxer is knocked down and cannot get up by the referee’s count of 10. A technical knockout (TKO) is one in which the referee or ringside doctor determines that the fighter is unable to defend himself or has sustained a serious injury, or when the fighter’s handlers throw in the towel
Vox populi Bombshell A woman who is stunningly beautiful

knock·out

, knock-out (nok'owt)
A genetically engineered organism in which the genome has been altered by site-directed recombination so that a gene is deleted.

knockout

see GENE DISRUPTION.
References in periodicals archive ?
The three-fight winning streak by knockout came after Ancajas captured the IBF super-flyweight crown (115 lb) by outpointing McJoe Arroyo of Puerto Rico in Taguig City in 2016.
The study includes Knockout venues in Armidale (1981, 1987, 2001), Dubbo (1984, 1999, 2000), Moree (1986, 1995, 2002), Walgett (1989), Sydney (1991, 1992), Bourke (1996), Nambucca Heads (1997, 1998, 2000) and Maitland (2003).
Thursday: Echo Knockout (third round): St Helens Recs v Northern, Liverpool v Hightown, Birkenhead Park v Alder, Ormskirk v Wavertree.
Evesham Technologies is shipping the Knockout immediately, with a three year warranty, with prices starting from GBP999 including VAT.
Hannon explains that creating a knockout mouse can take well over a year, while knocking down a gene with RNAi takes only a few days.
Switchcraft, which makes electrical parts for its corporate parent, Raytheon, also installed MUD's new quick-disconnect water manifolds and spring-loaded knockout bars.
8220;I am very excited to be a part of the Knockout team.
Goals from Matthew Rankin and Stephen Barnes sealed the success while Netherley WLL won the Knockout Cup, beating Woolton Tigers 5-0 with Jamie Blythe, Luke Wall and Adam Stephens amongst the goals.
Tokyo, Japan, Aug 29, 2005 - (JCNN) - TransGenic announced on August 26 that the Hyogo Prefectural Government has selected the company's research project on gene knockout mice as a project in its attempt to support industry-academia efforts to develop new businesses.