knockin model

knockin model

An animal model in which a specific mutation is introduced into a native gene, which enables assessment of the physiologic and pharmacologic roles of specific proteins and even small regions within proteins.
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References in periodicals archive ?
This latest extension includes grants from MJFF to support the in vivo phenotyping of an ?-synuclein knockout model and an ?-synuclein A53T knockin model, and establishment and validation of a pre-clinical model to test LRRK2 kinase inhibitors.
With MJFF support, Charles River has launched a new project, focused on in vivo phenotyping of an ?-synuclein knockout model and an ?-synuclein A53T knockin model.