knockdown


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The alteration of a gene’s function so that it is conditionally expressed, a manoeuvre required when complete gene knockout would be lethal to the organism

knockdown

A modification of a gene that limits its expression to specified conditions or circumstances.

knockdown

a measure of biocide effect that is used when it is difficult to assess actual mortality. The measure is used particularly in biocide tests on insects, and has been shown to produce similar results to actual mortality scores. Knockdown is often measured as the inability to respond to a stimulus such as light or touch. see KNOCKDOWN LINE.
References in periodicals archive ?
In rat primary myocardial fibroblasts, the PCNA expression was significantly increased in the AAT1 knockdown group ( F = 31.70, P < 0.01) and in the AAT2 knockdown group compared with the empty virus group ( F = 18.93, P < 0.01).
Sensitivity of PC3 xenografts to irradiation was enhanced by HULC knockdown
We found that knockdown of Bcor resulted in 10-fold and 3-fold increases in percentage of cTnT+ iCMs derived from ExCFs and fCFs, respectively, when compared to treatment of shNT (Figures 3(a) and 3(b)).
Lv et al., "Long non-coding RNA Linc-ITGB1 knockdown inhibits cell migration and invasion in GBCSD/M and GBC-SD gallbladder cancer cell lines," Chemical Biology and Drug Design, vol.
To further determine the role of CD38 in H/R-induced injury, CD38 expression vector was introduced into the wild type H9c2 cells or the CD38 knockdown H9c2 stable cell lines.
In the third round Golovkin sent his opponent to the second knockdown with a counter forehand blow.
The 26-year-old from Birtley survived three knockdowns from body shots in one round in an amazing battle, before stopping Preston's Matty Clarkson in Leeds on Saturday.
BE ON-TREND with a Kangol duffel coat with toggles and a faux fur hood - at a knockdown price of PS25.
Knockdown of RIG-I and TLR3 Attenuates the Activation of p38MAPK, ERK, AP-1, and NF-[kappa]B in JEV-Infected BV-2 Cells.
On the basis of the longer knockdown durations and mortality effects of the coils tested, the 0.3% d-allethrin coil should only be used as a supplement in minimizing vector-human contact and not as a sole protection measure.