knockout

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knock·out

, knock-out (nok'out, nok'-out),
A genetically engineered organism in which the genome has been altered by site-directed recombination so that a gene is deleted.

knockout

(nŏk′out′)
adj. also knock-out (nŏk′out′)
Genetics Having a specific single gene inactivated or removed by genetic manipulation: knockout mice used in an experiment.
Experimental biology A genetically engineered mutant animal—e.g., Drosophila, mouse, fish, et al—in which a targeted gene has been inactivated to facilitate analysis of the knocked-out gene’s activity and function
Molecular medicine adjective Referring to the inactivation of a specific gene or genes noun A lab organism—e.g., yeast or mouse—in which a specific gene is altered, inactivating it and creating a model for a particular disease; in knockouts, an extracellular signal is converted to a functional intracellular change
Sports medicine KO The vanquishing of an opponent in a combat sport by bringing the opponent to the mat or ground. In boxing, this is defined as when the boxer is knocked down and cannot get up by the referee’s count of 10. A technical knockout (TKO) is one in which the referee or ringside doctor determines that the fighter is unable to defend himself or has sustained a serious injury, or when the fighter’s handlers throw in the towel
Vox populi Bombshell A woman who is stunningly beautiful

knock·out

, knock-out (nok'owt)
A genetically engineered organism in which the genome has been altered by site-directed recombination so that a gene is deleted.

knockout

see GENE DISRUPTION.
References in periodicals archive ?
Docherty said: "If I can get six fights and six knock-outs I will definitely put my name out there.
Knock-out mice are currently produced by growing embryo-derived pluripotent stem cells in culture, creating targeted mutations in them and then transplanting them into preimplantation mouse embryos to produce a chimera that comprises normal recipient lineages as well as lineages derived from the mutant cells.
The victory in front of an adoring home support extended her win record to 30, of which 17 have been via knock-outs. The victory saw Zarika bestowed Head of State Commendation (HSC) honour by President Uhuru Kenyatta as Kenya celebrated her 54th Jamhuri Day on December 12.
As part of its sixth Ramadan Sports Festival, Aspire Zone Foundation will organise an indoor hockey tournament for men, with eight teams set to compete in knock-outs. The tournament, which will run for three days at Aspire Dome, the world's largest multi-purpose arena, follows the success of the Asian Nations Cup indoor hockey championship 2017, which took place in April.
Tenders are invited for Weather-Proof, Cable Junction Box Without Terminals For Outdoor Use With Following Specifications: - Material: Thermoplastic - Protection: Ip-65 - Cable Entry: Via Metric Knock-Outs - Front Facia / Cover: Opaque With 4 Screws On Corners - Color: White - Dimensions (+/- 5 Mm): Width-139 Mm, Height-119, Depth-70 Mm - Should Have Arrangements To Fix On Wall.
"He can obviously bang extremely hard and he has a lot of knock-outs on his record so it is an intriguing fight.
The next challenge the contestants face is the first stage of the knock-outs, in which they must carefully select and perform a 'killer song' that will elevate them above their team rivals, as the coaches whittle their eight chosen singers down to three.
Both could be knock-outs! Joshua is supported by a load of local talent, which is just as well because if you bend down to pick up your programme you will probably miss our Olympic golden boy delivering the coup de grace.
The heavy-handed Majiha boasts of his 15 wins, three losses, four draws, and seven knock-outs record, while Tapales improved made it to 18 wins, one defeat with six knock-outs after he demolished his Thai opponent Yodpichai Sithsaithong in only four rounds during his last fight.
Sowah is a 30-yearold from Ghana and has had back-to-back knock-outs to secure his title chance.
"The equity markets have reacted negatively due to questions over the credibility of the forward guidance knock-outs," James Butterfill, global equity strategist at Coutts, said.
"Recently he has had four wins, three via knock-outs, which indicates just how much power he has built into his punching.