knock-in

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knock-in

(nok′in″)

An engineered change in a genetic sequence in which an organism's natural gene is replaced by one with a modified nucleic acid sequence that produces a functional protein.

References in periodicals archive ?

Next, using transgenic mice with the G184S Gnai2 allele (knock-ins) which interrupts G-protein [alpha] unit binding to regulators of G-protein signaling (RGS), we found [[alpha].sub.2A]AR antiepileptic effects of EPI were enhanced in hippocampal slices from mutant G[[alpha].sub.0] to mice but not G[[alpha].sub.i2] mice.

RGS7 protein suppression of G[[alpha].sub.o] protein-mediated [[alpha].sub.2A]-adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity

In particular, IRES is important for evaluating the success of gene knock-outs or knock-ins in stem cells, which is crucial for the successful creation of transgenic mouse and rat disease models.

Stem Cell Sciences Licenses IRESTechnology

"I will be totally fair to them - I won't leave it until the last knock-ins and I'll tell them their futures will be sorted out a lot sooner than that.

IT'S A BALANCING ACT - McCARTHY

Next, using transgenic mice with the G184S Gnai2 allele (knock-ins) which prevents inhibition by interruption of the G-protein alpha unit binding to regulators of G-protein signaling (RGS), we found enhanced [[alpha].sub.2A]AR effects in hippocampal slices from mutant G[[alpha].sub.o] mice but not G[[alpha].sub.i2] mice.

RGS Protein suppression of G[[alpha].sub.o] protein-mediated [[alpha].sub.2A]-adrenergic inhibition of mouse hippocampal CA3 epileptiform activity

"Chris is progressing nicely and Foley who's just progressing to the last 'knock-ins' of the medial knee ligament," said McCarthy.

Kightly on the mend

"But he's at the last knock-ins of it now - he can run, but it's just kicking a ball.