Moreover, in a large-scale perturbation study, we will specifically address the role of the kinome
in antiviral innate immune signalling pathways, exploring the role of its individual members and their epistatic relationships in orchestrating gene expression.
One of the latest successes was the release of KinMap, a free web-based tool for creating and sharing interactive annotations of the human kinome
This kit can be used to improve the performance of any of Agilent's SureSelectXT2 custom and pre-defined panels including the exome, kinome
and inherited disease panels.
Dynamic reprogramming of the kinome
in response to targeted MEK inhibition in triple-negative breast cancer.
Blueprint deploys a library of novel compounds that covers a majority of the human kinome
, as highly selective starting points for drug development programs as well as tool compounds.
For the quail: 2/3 cup plum wine 1/2 ounce plum paste 1 1/2 teaspoons soy sauce 2 teaspoons sesame oil 2 1/2 teaspoons soy sauce 1 teaspoons garlic paste 1 teaspoon ginger paste 3 large quail, legs and breasts reserved, breasts boned To serve: Canola oil as needed Sea salt and freshly grated black and pink peppercorns to taste 2 ounces coarsely chopped umeboshi (pickled plums) For the garnish: Bamboo leaf Kinome
Twelve papers address genomic mapping and sequencing, databases, multigene families, regulation of gene expression, signal transduction, the microfilament system, the GTPase superfamily, the kinome
, glycosyltransferase genomics, and whole-genome functional analysis.
The paste on top of the tofu was a mixture of white miso (a type of sweet-tasting miso especially used in the western part of Japan), kinome
(young leaves of a kind of Japanese herb), and spinach.
Uncovering novel disease drivers and drug targets : New genomics and sequencing approaches are needed to elucidate the biology of the full kinome
, which is comprised of 518 kinases, and to uncover the function of kinases of unknown biology (or KUBs) and their potential for drug discovery.
With more than 465 kinases, RBC's activity assay coverage of the kinome
is the broadest in the industry.
RNAi screening of the tyrosine kinome
identifies therapeutic targets in acute myeloid leukemia.
The compound was profiled across >400 kinases covering all major families of the human kinome