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The complement of carbohydrate, lipid, and protein kinases in a genome.
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References in periodicals archive ?
Global signaling effects of a schizophreniaassociated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches.
These results are due to the fact that both tofacitinib and SOCS1/3 act on JAK with a high degree of kinome selectivity and display the same final biochemical effects of JAK inactivation.
Tonks, "Targeting the Kinome II," Current Opinion in Cell Biology, vol.
Goffin et al., "Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice," Proceedings of the National Academy of Sciences of the United States of America, vol.
Simultaneous inhibition of aberrant cancer kinome using rationally designed polymer-protein core-shell nanomedicine.
Wagner et al., "Profiling of the kinome of cytomegalovirus-infected cells reveals the functional importance of host kinases Aurora A, ABL and AMPK," Antiviral Research, vol.
Lussier, "Kinase inhibition-related adverse events predicted from in vitro kinome and clinical trial data," Journal of Biomedical Informatics, vol.
This kit can be used to improve the performance of any of Agilent's SureSelectXT2 custom and pre-defined panels including the exome, kinome and inherited disease panels.
These antidiabetic effects were not due to "off-target" effects of these compounds because (i) these compounds are structurally different (Figure 1), (ii) RO5126766 is specific to Raf/MEK and 10 [micro]mol x [L.sup.-1] RO5126766 did not inhibit any of the 256 other kinases in the Ambit KINOME scan panel [24, 26], (iii) RO4987655 is specific to MEK1/2 and 10 [micro]mol x [L.sup.-1] RO4987655 did not inhibit any of the 400 other kinases [28], and (iv) there were no toxic signs in db/db mice treated with these compounds for 17 days (Supplemental Tables S2 and S3).