kininogenases

kininogenases

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Apart from its kininogenase activity, tissue kallikrein has been implicated in the processing of growth factors and peptide hormones in light of its presence in pituitary, pancreas, and other tissues (31).
The study of substrate specificities between hK1 and hK2 reveals important differences, suggesting that the two proteins have different natural substrates, a notion that is supported by the finding of very low kininogenase activity of hK2 compared with hK1 (32,33).
Human kallikrein hK2 has low kininogenase activity while prostate specific antigen (hK2) has none.