bradykinin

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bradykinin

 [brad″e-ki´nin]
a nonapeptide kinin formed from a plasma protein, high-molecular-weight (HMW) kininogen by the action of kallikrein; it is a very powerful vasodilator that increases capillary permeability and, in addition, constricts smooth muscle and stimulates pain receptors.

bra·dy·ki·nin

(brad'ē-kī'nin),
The nonapeptide Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, produced from the decapeptide kallidin (bradykininogen) that is produced from α2-globulin by kallikrein, normally present in blood in an inactive form and similar to trypsin in action; bradykinin is one of several plasma kinins, is a potent vasodilator, and is one of the physiologic mediators of anaphylaxis released from cytotropic antibody-coated mast cells following reaction with antigen (allergen) specific for the antibody.
[brady- + G. kineō, to move]

bradykinin

(brăd′ĭ-kī′nĭn, -kĭn′ĭn)
n.
A biologically active polypeptide, consisting of nine amino acids, that forms from a blood plasma globulin and mediates the inflammatory response, increases vasodilation, and causes contraction of smooth muscle.

bradykinin

A vasoactive nonapeptide (RPPGFSPFR) formed by action of proteases on kininogens, which is very similar to kallidin (the same sequence, but with an additional N terminal lysine). It is a potent vasodilator, increasing the permeability of postcapillary venules and acting on endothelial cells to activate phospholipase A2; it is also spasmogenic for some smooth muscle and evokes pain.

bra·dy·ki·nin

(brad'ē-kī'nin)
The nonapeptide Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, normally present in blood in an inactive form; one of the plasma kinins, a potent vasodilator and mediator of anaphylaxis.
[brady- + G. kineō, to move]

bradykinin

A peptide that widens blood vessels (vasodilatation) and lowers blood pressure, increases capillary permeability and the secretion of saliva and mediates pain associated with inflammation. Bradykinin is inactivated by the angiotensin-converting enzyme.

bradykinin

a hormone formed from a kininogen in the blood plasma that has the effect of rapid VASODILATION in the skin.

bra·dy·ki·nin

(brad'ē-kī'nin)
One of several plasma kinins, a potent vasodilator; physiologic mediator of anaphylaxis released from cytotropic antibody-coated mast cells following reaction with antigen (allergen) specific for the antibody.
[brady- + G. kineō, to move]