kinetoplast


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Related to kinetoplast: Kinetoplastida

kinetoplast

 [kĭ-ne´to-plast]
an accessory body found in many protozoa, primarily the Mastigophora; it contains DNA and replicates independently.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ki·ne·to·plast

(ki-nē'tō-plast, ki-net'ō-),
An intensely staining rod-shaped, diskoid, or spheric extranuclear DNA structure found in parasitic flagellates (family Trypanosomatidae) near the base of the flagellum, behind the blepharoplast, and often at right angles to the nucleus. Visible by light microscopy, electron micrographs reveal it as part of a single giant mitochondrion filling most of the cytoplasm of amastigote flagellates. Identifying kinetoplast as kDNA distinguishes it from nuclear DNA(nDNA). The kinetoplast divides independently, but with the basal body, before nuclear division. Kinetoplast formerly included parabasal body and blepharoplast in a locomotory apparatus but is now recognized as a distinct organelle of most trypanosomatids.
See also: parabasal body.
[kineto- + G. plastos, formed]
Farlex Partner Medical Dictionary © Farlex 2012

kinetoplast

(kə-nĕt′ə-plăst′, -nē′tə-, kī-)
n.
A loop of DNA located in a large mitochondrion that lies near the base of the flagellum in certain protozoans.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

ki·ne·to·plast

(ki-nē'tō-plast)
An intensely staining extranuclear DNA structure found in parasitic flagellates near the base of the flagellum. Electron micrographs show it to be part of a single giant mitochondrion filling most of the cytoplasm of amastigote flagellates.
See also: parabasal body
[kineto- + G. plastos, formed]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

kinetoplast

see KINETOSOME.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
The architecture of the kinetoplast is crucial for replication and segregation of the kDNA circles because the molecules involved in these processes are precisely positioned in functional domains throughout the kinetoplast (Figure 2).
Englund, "Drug-promoted cleavage of kinetoplast DNA minicircles.
The Trypanosoma cruzi Satellite DNA OligoC-TesT and Trypanosoma cruzi Kinetoplast DNA OligoC-TesT for Diagnosis of Chagas Disease: A Multi-cohort Comparative Evaluation Study.
Electronic microscopy transmission studies with cells treated with pentamidine showed condensation and disruption of kinetoplast DNA core and collapse of mitochondrial membrane [39, 40].
Detection of Trypanosoma cruzi in blood specimens of chronic chagasic patients by polymerase chain reaction amplification of kinetoplast minicircle DNA: comparison with serology and xenodiagnosis.
At this magnification they were seen as an oval body with clear nucleus and sometimes a small kinetoplast. They were not seen in isolation but were always be in a group in the cytoplasm of a macrophage (Figure 1) Statistical analysis The sensitivity and specificity of slit-skin smear
These round forms are mostly without nucleus or kinetoplast and are devoid of dividing capabilities.
These studies revealed overexpression of metabolically significant proteins like carboxypeptidase, enolase, fructose-1, 6-bisphosphatase, Hsp70, and Hsp83 and downregulation of a kinetoplast membrane protein (KMP11) and calcineurin in R-strains [29-31].
[35] using the following primers to amplify a fragment of 330 bp: 121 (5'-AAA TAA TGT ACG GG(G/T) GAG ATG CAT GA-3')and 122(5'-GGT TCG ATT GGG GTT GGT GTA ATA TA-3') from a nonvariant region of the kinetoplast DNA minicircles of T.
Barker, "Diagnosis of new world leishmaniasis: specific detection of species of the Leishmania braziliensis complex by amplification of kinetoplast DNA," Acta Tropica, vol.
Sensitive detection and schizodeme classification of Trypanosoma cruzi cells by amplification and kinetoplast minicircle DNA sequences: use in diagnosis of Chagas disease.
Leishmain stain of blood film revealed trypomastigote form of Trypanosoma brucei having long cylinder body, central nucleus and undulating membrane with long flagellum arising from kinetoplast located at posterior end (Fig 1).