Spatial regulation of kinetochore
microtubule attachments by destabilization at spindle poles in meiosis 1.
A mechanomolecular model for the movement of chromosomes during mitosis driven by minimal kinetochore
Maloriented bivalents have metaphase positions at the spindle equator with more kinetochore
microtubules to one pole than to the other.
EGFP fusion proteins can be used in modern fluorescence microscopy techniques to determine
analysis of micronuclei allows insights into the actions of colcemid and mitomycin C.
HZwint-1, a novel human kinetochore
component that interacts with HZW10.
Objective: Accurate chromosome segregation in eukaryotes requires the assembly of the macromolecular kinetochore
complex at centromeres to attach chromosomes to the mitotic spindle.
gamma]-Tubulin is more concentrated in the poles where it forms a distinct cap and extends along the distal kinetochore
fibers especially those at the perimeter of the spindle (Fig.
Micronuclei were scored as centromere negative (clastogenic) or centromere positive (aneugenic) based on the presence of CREST staining, which recognizes centromere proteins within the kinetochore
of each chromosome, within each micro-nucleus.
1973 Differentiation of the synaptonemal complex and the kinetochore
in Locusta spermatocytes studied by whole mount electron microscopy.
Since the microtubules seem to be disassembling at the kinetochore
, where they're attached to the chromosome, some investigators have proposed that the kinetochores
cause this shortening by munching away on tubulin like Pac Man.
Of interest, in yeast Saccharomyces cerevisiae the spores that are the meiotic products of the sporulation of diploid cells display a lineage-specific asymmetric division of kinetochore