KIF2A

(redirected from kinesin-2)

KIF2A

A gene on chromosome 5q12-q13 that encodes a microtubule-associated motor protein required for normal brain development, which may regulate microtubule dynamics during axonal growth. KIF2A is required for normal progression through mitosis for normal congress of chromosomes at the metaphase plate, and is also required for normal spindle dynamics during mitosis. KIF2A promotes spindle turnover and is implicated in formation of bipolar mitotic spindles. It has microtubule depolymerisation activity.
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References in periodicals archive ?
The transport of ciliary proteins from the cytoplasm to the ciliary tip, known as anterograde transport, depends on the heterotrimeric kinesin-2 protein, which consists of two motor subunits, KIF3A and KIF3B, and an accessory subunit, the kinesin-associated protein (KAP) [18].
They identified the proteins, which include the motor protein kinesin-2, and found that when these proteins were missing the microtubules no longer pointed the same way in dendrites; that is, their polarity became disorganized.
"When we disabled the flies' ability to produce the kinesin-2 protein, we found that the highways could not be rebuilt correctly, and nerve regeneration failed," Rolls explained.
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