KIF5B

(redirected from kinesin-1 heavy chain)

KIF5B

A gene on chromosome 10p11.22 that encodes a microtubule-dependent motor protein required for normal distribution of mitochondria and lysosomes.
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Yang reported that translocation of the MI spindle to the cortex requires microtubules and MEI-1/katanin (Yang et al., 2003) and these investigators also identified a complex which is composed of the kinesin-1 heavy chain orthologue, UNC-116, the kinesin light chain orthologues, KLC-1 and -2, and a novel cargo adaptor, KCA-1, suggesting that kinesin-I motor activity might directly translocate the spindle to the cortex.

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