KLRB1

(redirected from killer cell lectin-like receptor subfamily B, member 1)

KLRB1

A gene on chromosome 12p13 that encodes a C-type lectin domain protein which is expressed in natural killer (NK) cells and is involved in regulating their activity. KLRB1 inhibits NK-cell cytotoxicity and enhances anti-CD3-induced T-cell proliferation.
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Additionally, the cell surface expression of the following NK cell inhibitory receptors was determined: NKG2A creating a complex with CD94 molecule, a killer cell immunoglobulin-like receptor (KIR2DL2/L3/CD158b, NKAT2), a member of the leukocyte immunoglobulin-like receptor (LIR) family such as the immunoglobulin-like transcript 2 (LIR1/ILT-2/CD85j), and a killer cell lectin-like receptor subfamily B, member 1 (KLRB1) also known as NKR-P1A/CD161.