killer T-cells

killer T-cells

cytotoxic T-LYMPHOCYTES which recognize and kill virus-infected cells, transplanted cells from a genetically-dissimilar member of the same species (allogeneic transplant), possibly cancer cells and other abnormal cells. They recognize foreign antigens on the surface of the target cells, release lysosomal enzymes (see LYSOSOME and perforins (which form ion-permeable channels in the cell membrane), and destroy the cells on contact. After killing the target cells, killer T-cells continue to live and can kill repeatedly. Killer T-cells are the effector of cell-mediated IMMUNE RESPONSE.
Mentioned in ?
References in periodicals archive ?
PDS biotechnology's Versamune platform is based on novel and proprietary synthetic cationic lipids, which promote critical intra-cellular delivery of tumor-related antigens and activate important immunologic signaling pathways that induce effective priming and proliferation of critical populations of killer T-cells able specifically to attack and kill cancerous cells.
These killer T-Cells are assisted by helper T-Cells that coordinate the attack and send chemical messages asking the killer T-Cells to multiply.
Killer T-cells (cytotoxic T-lymphocytes) attack pathogenic cells and are particularly useful for fighting viruses.
This CAR-T technology is initially focused on ovarian cancer, by engineering killer T-cells with the follicle stimulating hormone (FSH) to target ovarian cells that express the FSH-receptor.
In tests on mouse cells, the researchers found that when cancer cells are stressed by an experimental anti-CD47 immunotherapy, the cancer cells leak DNA into nearby dendritic cells, which present antigens to killer T-cells and are considered a bridge between the innate and adaptive immune systems.
Fortunately, scientists have discovered a substance called undenatured type II collagen, or UC-II[R], that retrains killer T-cells (which destroy target cells) so that they recognize collagen as a harmless substance--preventing the joint damage seen in osteoarthritis.
The cells are modified by adding a natural killer t-cell ligand, which permits them to stimulate natural killer T-cells, along with an antigen associated with a cancer.
T-cells secrete cytokines that direct activity of other immune cells (helper T-cells), recognise and destroy virus-infected body cells (killer T-cells) and prevent the immune system from over-reacting (regulatory T-cells).
Killer T-cells are an important component of our immune system.
The researchers want to make a vaccine from a component of the early killer T-cells.
It also produces killer T-cells that eliminate infected cells.