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The active principle in extracts of Ammi visnaga, an umbelliferous plant growing in the Near East; used in angina pectoris and asthma.
[Ar. khella]
Farlex Partner Medical Dictionary © Farlex 2012
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Improved high-performance liquid chromatographic determination of khellin and visnagin in Ammi visnaga fruits and pharmaceutical formulations.
Keywords: Ammi visnaga Nephrolithiasis Hyperoxaluria Calcium oxalate Khellin Visnagin
Further, in order to obtain information about possible active ingredients the two major khella compounds khellin and visnagin were investigated for possible preventive effects on cell damage.
Khellin (97% purity), visnagin (97% purity), oxalic acid and calcium oxalate monohydrate were purchased from Sigma Aldrich (St.
Quantitative determination of khellin and visnagin in KE by HPLC
Khellin and visnagin were identified by their spectrum at 330 nm using reference compounds.
Exposure of khellin and visnagin to LLC-PK1 and MDCK were conducted using the same Ox and COM concentrations as mentioned above.
The marker compounds khellin and visnagin were quantitatively determined in an aqueous extract prepared from the crushed fruits of Ammi visnaga L.
Since 100 of KE on the release of LDH in both cell lines revealed more consistent effects this concentration was chosen to calculate the corresponding amount of khellin and visnagin.
The regular daily administration of inhaled corticosteroids (beclomethasone, budesonide, and fluticasone) and/or khellin derivatives (cromoglycate and nedocromil) greatly assist in the control of asthma and EIA in athletes who are tempted to inhale larger quantities of salbutamol.
Its main agent, Khellin, is completely bioavailable already after 10 min, in favourable comparison to pure equimolar Khellin, which is not fully resorbed until 60 min (Eder and Mehnert 2000).