ketotifen

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Related to ketotifen: Ketotifen fumarate

ketotifen

[ke″to-ti´fen]

a noncompetitive H₁-receptor antagonist and mast cell stabilizer; used as the fumarate salt, administered orally in the chronic treatment of children with mild atopic asthma and topically to the conjunctiva as an antipruritic in the treatment of allergic conjunctivitis.

ketotifen

A drug that prevents the release of HISTAMINE and other irritating substances from MAST CELLS in allergic conditions. Its action is similar to that of CROMOGLYCATE (cromoglicate) but has the disadvantage of causing drowsiness. A brand name is Zaditen.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

antihistamine

Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.

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References in periodicals archive ?

One patient still requires ketotifen therapy with concurrent diphenhydramine therapy to tolerate antibiotics, Dr.

Prophylactic Ketotifen Reduces Allergic Reactions to Antibiotics

Antiallergic action of betostatine besilate (TAU-284) in animal models: a comparison with ketotifen. Pharmacology 57, 206-214.

Inhibition of histamine-induced bronchospasm in guinea pigs treated with Cecropia glaziovi Sneth and correlation with the in vitro activity in tracheal muscles

Moreover, in vivo investigations with compound 48/80 and mast cell stabilizing agents including ketotifen and sodium cromoglycate should be carried out by constituting animal models of migraine pain.

Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain/Mast Hucre Degranulasyonu Compound 48/80 ile Tetiklenmis Migren Agrisinin Altinda Yatan Meningeal Vazodilatasyona Aracilik Ediyor

Pharmacological mast cell stabilization (ketotifen) and tryptase and chymase inhibition (nafamostat and NK3201, resp.) decrease mucosal damage in TNBS colitis [37-40].

Mast Cells Exert Anti-Inflammatory Effects in an [IL10.sup.-/-] Model of Spontaneous Colitis

sodium cromoglycate, nedocromil sodium, pemirolast, and lodoxamide; (3) Dual acting agents - they have both antihistaminic and mast cell stabilizing properties, e.g., olopatadine, ketotifen, azelastine, and epinastine; (4) Non-steroidal anti-inflammatory drugs, e.g., ketorolac, diclofenac, and flurbiprofen; (5) Corticosteroids, e.g., prednisolone, hydrocortisone, fluorometholone, loteprednol, and desonide.

Clinical effectiveness of olopatadine therapy in children with allergic conjunctivitis

A wide variety of pharmacological agents have been used in treating cough, such as antibiotic, ketotifen, asmeton, dextromethorphan, and ICSs [68].

Clinical Effects and Safety of Zhi Sou San for Cough: A Meta-Analysis of Randomized Trials

Koopman et al., "The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome," Gut, vol.

The Role of Mast Cells in Irritable Bowel Syndrome

Gabapentin and ketotifen are two drugs used for treating uremic patients.The aim of this study was to compare gabapentin and ketotifen in treatment of uremic pruritus in hemodialysis patients.

Comparison of gabapentin and ketotifen in treatment of uremic pruritus in hemodialysis patients

There are no human eye data for bepotastine (Bepreve), ketotifen (Alaway), and olopatadine (Pataday, Patanol).

Ophthalmic drugs in pregnancy and lactation

Among topical antihistamines and anti-allergy drugs, ketotifen, olopatadine and epinastine are category C drugs; sodium cromoglycate and emedastine are in category B.

Pregnancy and the eye

For ocular symptoms of allergic rhinitis, patients may benefit from available O-T-C ophthalmic antihistamines, or ketotifen fumarate, an ophthalmic antihistamine/mast cell stabilizer.

O-T-C options for hay fever

Ketotifen fumarate (Zaditor) is an available over-the-counter treatment option, but olopatadine HC1 (Pataday) is the most popular prescription written by pediatricians.