Roberts, "Update on macrolide-lincosamide-streptogramin, ketolide
, and oxazolidinone resistance genes," FEMS Microbiology Letters, vol.
An example of this concept is a recent investigation into the ketolide
antibiotic PF-04287881, which was abandoned from pharmaceutical development following observation of liver biomarker elevations in clinical trials that were not predicted by classical rodent stocks used in preclinical screens (Mosedale et al.
Majority of them (6) were beta-lactams (Cephalosporins); a Macrolide (ketolide
) Erythromycin class from actinomycete; Lipopeptide (Daptomycin) from actinomycete; Tetracycline from actinomycete; Pleuromutilin from Pleuromutilin fungus and Glycopeptide (Vancomycin) from actinomycete.
Resistance to macrolide, lincosamide, streptogramin, ketolide
, and oxazolidinone antibiotics.
In the present study, attempt has been made to evaluate cytotoxic potential in terms [IC.sub.50] and leakage of marker enzymes for drugs from macrolide and ketolide
series and further comparison of [IC.sub.50] with [MIC.sub.50] (Clark et al., 2003) from literature data to calculate the safety margin of these antibiotics.
The newer classes of streptogramins (Synercid[R]) and oxazolidinones (Zyvox[R]), both used to treat drug resistant staphylococcal infections, also work by inhibiting protein synthesis, as does the new ketolide
, telethromycin (Bryskier, 2005c.)
centers during the 4 years of the global PROTEKT (Prospective Resistant Organism Tracking and Epidemiology for the Ketolide
centers within the 4 years of the global PROTEKT (Prospective Resistant Organism Tracking and Epidemiology for the Ketolide
antibiotic remains approved for treatment of mild to moderate community-acquired pneumonia (CAP) in patients aged 18 and over.
Telithromycin (Ketek[R]) is a ketolide
antibiotic which blocks bacterial protein synthesis.
(48) found that in vivo drug disposition of ABT-773, a ketolide
antibiotic that is a substrate for both CYP3A and P-glycoprotein, depends on the CYP3A5, but not the MDR1 genotype.