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Specific serotonin 5HT2-receptor antagonist with antihypertensive properties; the drug also reduces platelet aggregation produced by serotonin. Shown to reduce the severity and frequency of the vasospasm in Raynaud's phenomenon.
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The most commonly used is ketanserin (KTS) which has been approved for wound treatment by The Federal Commission for the Protection against Sanitary Risk (COFEPRIS) under registry number 259M90 SSA [24].
By contrast, when platelets were stimulated with higher concentrations of 5-HT, there was a significant decrease in platelet activation following the attainment of the peak level of 5-HT concentration.[sup][25] Moreover, it has been shown that these effects can be inhibited by 5-HT[sub]2AR blockers such as ketanserin, which suppresses 5-HT release and protects the heart against ischemia.[sup][26],[27],[28] Since elevations of platelet 5-HT[sub]2AR have been found in depressed patients, these studies suggest that 5-HT[sub]2AR may constitute the pathophysiological cause of co-occurring MI and depression.
Subchronic treatment with fluoxetine and ketanserin increases hippocampal brainderived neurotrophic factor, [beta]-catenin and antidepressantlike effects.
In addition, the serotonin receptor antagonist ketanserin is known to inhibit larvae from metamorphosing in response to NOS inhibitors and nicotinamide (Biggers et al., 2012; Bums et al., 2014).
Effects of MDMA (Ecstasy) on Prepulse Inhibition and Habituation of Startle in Humans after Pretreatment with Citalopram, Haloperidol, or Ketanserin. Neuropsychopharmacology 2001; 24:240-252.
And it was 5HT) found that liver regeneration would be arrested when ketanserin was administrated to block 5/HT2, a subtype of 5/HT, approximately at the G1/S transition point [41].
Although some drugs have been successfully used in certain cases, for example, cyproheptadine, ketanserin, 5-HT receptor antagonists, corticosteroids, and H1- and H2-receptor antagonists [15], somatostatin analogues are considered most effective and are recommended as first-line therapy [8, 9, 26].
An interesting alternative is ketanserin, a serotonin receptor antagonist.
Pazos, "Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, [beta]-catenin and antidepressant-like effects," British Journal of Pharmacology, vol.
Molecule in cMap Enrichment score P value Isoflupredone -0.928 0.00054 Trihexyphenidyl -0.922 0.00080 Prestwick-691 -0.856 0.00599 Ajmaline -0.834 0.00903 Carteolol -0.754 0.00734 Thiamphenicol -0.672 0.00883 DL-thiorphan 0.942 0.00632 Milrinone 0.903 0.00182 Apigenin 0.873 0.00036 Ronidazole 0.852 0.00611 Skimmianine 0.835 0.00115 Chrysin 0.826 0.01064 Rottlerin 0.825 0.01074 Clomipramine 0.787 0.00400 Deptropine 0.783 0.00412 Sulconazole 0.783 0.00416 Ethaverine 0.741 0.00863 Ketanserin 0.727 0.01110 Prestwick-685 0.670 0.01045 Resveratrol 0.536 0.00558