Our approach was to attempt noninvasive
keratolytic therapy before considering retinoids or surgical options; we also recommended steroid treatment for symptom relief.
In spite of intensive antibiotic treatment, corneal damage can occur as a result of
keratolytic and inflammatory process caused by infection or scarring and of neovascularisation relating to the healing process1.
Olive oil is known to be beneficial in the treatment of psoriasis by increasing hydration of the stratum corneum and through the
keratolytic effect (Ruiz et al.
In patients with severe skin lesions or who don't want to continue the treatment, anti-TNF therapy should be suspended and replaced by administration of more aggressive local therapy (corticosteroids,
keratolytic agents, vitamin D analogues) under the supervision of a dermatologist.
Potent topical corticosteroids, topical calcineurin inhibitors,
keratolytic agents, topical dimethyl sulfoxide (DMSO), intralesional corticosteroids, PUVA and UVB phototherapy, systemic retinoids, low-dose cyclophosphamide, cyclosporine have been used for medical management of LA.
Topical cantharidin caused blisters and necessitated more visits, and topical
keratolytic was irritating.
They have very good
keratolytic and comedolytic effects.
Keratolytic agents (urea salicysilic acid and alpha hydroxylic acid) are used to enhance corneocyte disadhesion.
It has got antifungal, antibacterial, and
keratolytic properties.
Other research topics included specifically South African subjects, such as reconstructing the history of preliterate peoples of the subcontinent employing blood groups and protein characteristics, oculocutaneous albinism in the black population, TSD in Jewish people, pentosuria, cystic fibrosis, Fanconi's anaemia, fragile X syndrome, the Y chromosome, mitochondrial DNA, haemoglobin variation (haemoglobinopathies) and disorders in the black and Indian populations,
keratolytic winter erythema, lipoid proteinosis, intellectual disability, fetal alcohol syndrome, and other rarer conditions.
Selenium sulphide is well known for
keratolytic and keratoplastic activity by reducing epidermal turnover and impairing disulphide bridge formation and antiseborrhoeic activity (Halliwell, 1991; Scott et al.
Treatment includes hydration, lubrication,
keratolytic application and oral acitretin.
