keratohyalin granules


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ker·a·to·hy·a·lin gran·ules

irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis.
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B, Higher magnification reveals features of epidermolytic hyperkeratosis: cytoplasmic vacuolation, coarse keratohyalin granules, and perinuclear eosinophilic inclusions in the spinous and granular layers (hematoxylin-eosin, original magnifications X40 [A] and X400 [B]).
FLG is produced in the SG as profilaggrin (FLG polymer) and is stored in keratohyalin granules. At the transition to the SC, the polymer is processed to the monomer by proteases such as Prss8 and SASPase [28, 29] and then binds to keratin and forms the fundamental structure of the corneocytes.
The histopathologic examination revealed a cyst decorated with squamous epithelium devoid of keratohyalin granules (Figure 2 A,B).
Histopathological studies showed inhibition in cellular infiltration and reduction of synovial hyperplasia and synovitis, whereas in the second test, histopathological and ultrastructural studies showed that topical application of FAM induced orthokeratosis with the presence of keratohyalin granules in the previously parakeratotic adult mouse tail, and without effects on epidermal thickness.