keratocyte


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Related to keratocyte: echinocyte

ker·a·to·cyte

(ker'ă-tō-sīt),
The fibroblastic stromal cell of the cornea.
An erythrocyte formed when haemoglobin denatures—as occurs in alpha-thalassemia or G6PD deficiency—and precipitates—due to oxidation—into clumps (Heinz bodies) that stick to the red cell membrane; the spleen ‘pits out’ a fragment of membrane with precipitated haemoglobin as the cells pass through the sinusoids, hence the term ‘bite’

schistocyte

A fragmented red cell which arises from either an intrinsic increase in cell fragility or due to intravascular rugosities that traumatise cells; schistocytes are a nonspecific finding seen in hemolysis, trauma, prosthetic heart valves, megaloblastic and microangiopathic anaemioccidianhemolytic uremic syndrome, TTP.

ker·a·to·cyte

(ker'ă-tō-sīt)
1. The fibroblastic stromal cell of the cornea.
2. A variety of poikilocyte that owes its abnormal shape to fragmentation occurring as the cell flows through damaged small vessels.
Synonym(s): schistocyte.

keratocyte

1. One of the cells of the main body of the CORNEA.
2. An abnormally-shaped red blood cell bearing horn-like projections. Keratocytes may occur in cases of poisoning or adverse drug reactions in which the red cells are damaged.

corneal corpuscle 

Main cellular element of the corneal stroma. It is a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which may communicate with neighbouring cells. These cells have fibroplastic and phagocytic functions. Syn. corneal fibrocyte; fixed cell; keratocyte.
References in periodicals archive ?
Wilson, "Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbits," Journal of Refractive Surgery, vol.
Guthoff, "The keratocyte network of human cornea: A three-dimensional study using confocal laser scanning fluorescence microscopy," Cornea, Vol.
However, if the increase in the level of the ones in the form of lactate is more than the discharge, it gathers in the stroma by creating an osmotic load and corneal edema happens in there.14 The reason for 2% thinning in the cornea after edema has disappeared is the worsening and potential keratocyte death.
These include increased inflammatory mediators and loss of keratocytes, abnormal enzyme function and loss of collagen, anomalous keratocyte function and altered fibrillogenesis, altered proteoglycan production, reduced tensile strength, collagen slippage in cone, and cone formation by biomechanically coupled curvature transfer.
Vasiliou, "Myofibroblast differentiation modulates keratocyte crystallin protein expression, concentration, and cellular light scattering," Investigative Ophthalmology and Visual Science, vol.
Histopathologic features include changes in corneal collagen structure and organization, alterations of the extracellular matrix, and keratocyte apoptosis and necrosis involving the anterior stroma and Bowman's layer, iron deposition in the epithelial basement membrane, and breaks in the Bowman lamina, which partially explain the biomechanical corneal weakening typical of the disease [7].
The increased collagen fiber diameter [8], keratocyte apoptosis, and subsequent transformation into myofibroblasts [9] are the reported corneal changes on transmission electron microscopy that interpret the reduction in corneal transparency noted post-CXL.
Because anatomical regularity of the collagen fibrils, integrity of connective tissue, and balanced keratocyte components play an important role in corneal clarity, it can be hypothesized that corneal densitometry may be altered in the presence of a systemic inflammatory disease, even in the absence of any corneal haze or scar.
Wilson, "Keratocyte apoptosis associated with keratoconus," Experimental Eye Research, vol.
Shin, "Combined treatment with antioxidants and immuno-suppressants on cytokine release by human peripheral blood mononuclear cells--chemically injured keratocyte reaction," Molecular Vision, vol.